Summary
A sorting signal which directs the prohormone pro-opiomelanocortin (POMC) to the regulated secretory pathway was identified. This sorting signal motif consists of a 13 amino acid (POMC8–20) amphipathic loop stabilized by a disulfide bridge (Cys8–Cys20) located at the N-terminus of pro-opiomelanocortin. It binds at an acidic pH specifically to an ~64 kD sorting receptor protein present in Golgi and secretory granule membranes of neuroendocrine cells. These findings support the hypothesis that pro-opiomelanocortin is targeted to the regulated secretory pathway by a receptor-mediated mechanism.
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© 1996 Birkhäuser Verlag Basel/Switzerland
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Loh, Y.P., Snell, C.R., Cool, D.R. (1996). Evidence for a receptor-mediated mechanism for sorting proopiomelanocortin to the regulated secretory pathway. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_6
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DOI: https://doi.org/10.1007/978-3-0348-9010-6_6
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