Summary
The aim of this study was to evaluate somatostatin receptor scintigraphy (SRS) in patients with suspected meningeoma. Prior to surgery 59 patients were investigated up to 24 h following an injection of 200 MBq In-111-octreotide. Tracer uptake was tested for the presence of meningeoma. Histology revealed 43 meningeoma and 16 other tumours. True positive SRS was obtained in 36 patients. Tumour volume was > 10 ml in 23 patients. False negative SRS was seen in 7 patients. All of them had a tumour volume of < 10 ml. While magnetic resonance imaging (MRI) alone was decisive in 39 of 48 patients, MRI could only limit differential diagnosis to meningeoma versus neurinoma in the remaining 9 patients. Out of these, positive SRS confirmed meningeoma in 5 patients, and negative SRS excluded meningeoma in 4 patients. In conclusion, there is significant clinical benefit of functional imaging with In-111-octreotide in patients with suspected meningeoma: Large meningeoma can be excluded by scintigraphy alone, while meningeoma of any size may be confirmed in combination with specific MRI results only.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bydder, G.M., Kingsley, P.E., Brown, J., Wiendorf, H.P. and Young, LR. (1985) MR imaging of meningeomas including studies with and without gadolinium-DM. J Comput. Assist. Tomogr. 9: 690–697.
Hildebrandt, G., Scheidhauer, K., Luyken, C., Schicha, H., Klug, N., Dahms, P. and Krisch, B. (1994) High sensitivity of the in vivo detection of somatostatin receptors by “’Indium-[DTPA-octreotide]-scintigraphy in meningeoma patients. Acta Neurochir. Wien 126: 63–71.
Huk, W.J., Gademann, G. and Friedmann, G. (1990) Magnetic resonance imaging of central nervous system disease. Springer, Berlin Heidelberg New York.
Koper, J.W., Markstein, R., Kohler, C., Kwekkeboom, D.J., Avezaat, C.J.J., Lamberts, S.W.J. and Reubi, J.C. (1992) Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth. J. Clin. Endocr. Metab. 74: 543–547.
Krenning, E.P., Kwekkeboom, D.J., Bakker, W.H., Breeman, W.A.P., Kooij, P.P.M., Oie, H.Y., van Hagen, M., Postema, P.T.E., de Jong, M., Reubi, J.C., Reijs, A.E.M., Hofland, L.J., Koper, J.W. and Lamberts, S.W.J. (1993) Somatostatin receptor scintigraphy with [’“In-DTPA-D-Phel]- and [123Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur. J. NucL Med. 20: 716–731.
Maini, C.L., Tofani, A., Sciuto, R., Carapella, C., Cioffi, R. and Crecco, M. (1993) Scintigraphic visualization of somatostatin receptors in human meningiomas using 111-indium-DTPA-D-Phe-l-octreotide. Nucl. Med. Commun. 14: 505–508.
Maini, C.L., Cioffi, R.P., Tofani, A., Sciuto, R., Fontana, M., Carapella, C.M. and Crecco, M. (1995) In-111octreotide scintigraphy in neurofibromatosis. Eur. J. Nucl. Med. 22: 201–206.
McConachie, N.S., Worthington, B.S., Cornford, E.J., Balsitis, M., Kerslake, R.W. and Jaspan, T. (1994) Review article: Computed tomography and magnetic resonance in the diagnosis of intraventricular cerebral masses. Br. J. Rad 67: 223–243.
Reubi, J.C., Krenning, E.P., Lamberts, S.W.J. and Kvols, L. (1993) In vitro detection of somatostatin receptors in human tumours. Digestion 54 (Suppl. 1): 76–83.
Reubi, J.C., Kvols, L., Krenning, E.P. and Lamberts, S.W.J. (1991) In vitro and in vivo detection of somatostatin receptors in human malignant tissue. Acta Oncol. 30: 463–468.
Reubi, J.C., Laissue, J., Krenning, E.P. and Lamberts, S.W.J. (1992) Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications. J. Steroid. Biochem. Molec. Biol. 43: 27–35.
Reubi, J.C., Lang, W., Maurer, R., Koper, J.W. and Lamberts, S.W.J. (1987) Distribution and biochemical characterization of somatostatin receptors in tumours of the human central nervous system. Cancer Res. 47: 5758–5764.
Reubi, J.C., Maurer, R., Klijn, J.G.M., Stefanko, S.Z., Foekens, J.A., Blaauw, G., Blankenstein, M.A. and Lamberts, S.W.J. (1986) High incidence of somatostatin receptors in human meningiomas: biochemical characterization. J. Clin. EndocrinoL Metab. 63: 433–438.
Sachs, L. (1984) Applied Statistics. A Handbook of Techniques. Springer, Berlin Heidelberg New York.
Scheidhauer, K., Hildebrand, G., Luyken, C., Schomäcker, K., Klug, N. and Schicha, H. (1993) Somatostatin receptor scintigraphy in brain tumours and pituitary tumours: first experiences. Horm. Metab. Res. 27: 59–62.
von Werder, K. and Faglia, G. (1992) Potential indications for octreotide in endocrinology. Metabolism 9 (Suppl. 2): 91–98.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Bohuslavizki, K.H. et al. (1996). Impact of somatostatin receptor scintigraphy in differential diagnosis of meningeoma. In: Krisch, B., Mentlein, R. (eds) The Peptidergic Neuron. Advances in Life Sciences. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9010-6_36
Download citation
DOI: https://doi.org/10.1007/978-3-0348-9010-6_36
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-9866-9
Online ISBN: 978-3-0348-9010-6
eBook Packages: Springer Book Archive