Summary
The microvasculature consists of endothelial cells (EC) with albuminally located pericytes. A number of clinical and experimental observations suggest that pericytes contribute to the regulation of microvascular growth and function. EC and pericytes appear to have a variety of means whereby they may influence one another, including soluble growth factors, gap junctions and adhesion molecules, to name a few. Co-culture systems have provided a good deal of evidence to support the concept that these two cells interact and that these communications are central to vessel assembly, growth control and normal function.
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© 1997 Birkhäuser Verlag Basel, Switzerland
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Hirschi, K.K., D’Amore, P.A. (1997). Control of angiogenesis by the pericyte: Molecular mechanisms and significance. In: Goldberg, I.D., Rosen, E.M. (eds) Regulation of Angiogenesis. Experientia Supplementum, vol 79. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9006-9_18
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DOI: https://doi.org/10.1007/978-3-0348-9006-9_18
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