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Response to ischemia and reperfusion by the diabetic heart

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

Abstract

Diabetes results in a number of diverse metabolic alterations among which is an elevation in circulating free fatty acids and a resulting increased reliance of the heart on fatty acids as an energy substrate [1]. In addition, one of the most notable changes at the myocardial level is decreased glucose transport into cells [2]. Membrane transport of ions may also be affected [3–6]. Decreased glucose uptake is directly related to a reduction in the content of glucose transporter proteins [2]. Other effects may result indirectly from altered cellular metabolism and from cellular and subcellular membrane changes.

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Authors and Affiliations

  1. Laboratoire de Physiologie Cellulaire, Université Paris XI, 91405, Orsay, France

    D. Feuvray

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  1. D. Feuvray
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Berkhäuser Verlag Basel/Switzerland

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Feuvray, D. (1996). Response to ischemia and reperfusion by the diabetic heart. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_24

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_24

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

  • eBook Packages: Springer Book Archive

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