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Myocardial protection for cardiac surgery

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

Abstract

The vast majority of cardiac surgical procedures are carried out using aortic cross-clamping and cardioplegie arrest [1]. Although alternate approaches such as operating on the normothermic empty beating heart, intermittent aortic cross-clamping or hypothermic ventricular fibrillation can be successfully utilized, the ability to carry out a meticulous and complete surgical procedure is generally best accomplished with the heart bloodless and still. Protective strategies in cardiac surgery are directed at both minimizing and reversing myocardial injury, which may occur not only secondary to ischemia induced with aortic cross-clamping, but also at the time of reperfusion. The ability to protect and resuscitate the heart from ischemic/reperfusion injury is of particular importance in patients with severe or complex disease, acute ischemia and/or compromised ventricular function.

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Author information

Authors and Affiliations

  1. Division of Cardiovascular Surgery, University of Western Ontario, London, Ontario, Canada, N6B 1B8

    M. L. Myers

  2. Division of Cardiovascular Surgery, University of Toronto, Toronto, Ontario, Canada, M4N 3M5

    S. E. Fremes

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  1. M. L. Myers
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Berkhäuser Verlag Basel/Switzerland

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Myers, M.L., Fremes, S.E. (1996). Myocardial protection for cardiac surgery. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_21

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_21

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

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