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Signal transduction mechanisms in the ischemic and reperfused myocardium

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Myocardial Ischemia: Mechanisms, Reperfusion, Protection

Part of the book series: EXS ((EXS,volume 76))

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Abstract

Ischemic heart disease is currently one of the greatest causes of mortality in our society. As such, extensive research into the causes and consequences of myocardial ischemia has been conducted. Ischemia may be defined as any condition resulting in an imbalance of oxygen supply and demand resulting in a change from aerobic metabolism to anaerobic glycolysis. This metabolic change has been associated with alterations in electrolyte balance and accumulation of metabolic products which can result in decreased cardiac function and the generation of life threatening arrhythmias. Since second messengers are critical for the regulation of cardiac function in non-ischemic myocardium, it is important to understand the possible changes in signal transduction during ischemia as well as reperfusion of ischemic myocardium. Information regarding altered signal transduction is potentially beneficial in the creation both of new drugs and therapeutic strategies which would minimize tissue damage associated with ischemia and reperfusion injury.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, The University of Western Ontario, N6A 5C1, London, Ontario, Canada

    C. A. Ward, M. P. Moffat & Morris Karmazyn

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  1. C. A. Ward
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  2. M. P. Moffat
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Western Ontario, Medical Sciences Building, N6A 5C1, London, Ontario, Canada

    Morris Karmazyn PhD (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario) (Professor and Career Investigator of the Heart and Stroke Foundation of Ontario)

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Ward, C.A., Moffat, M.P., Karmazyn, M. (1996). Signal transduction mechanisms in the ischemic and reperfused myocardium. In: Karmazyn, M. (eds) Myocardial Ischemia: Mechanisms, Reperfusion, Protection. EXS, vol 76. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8988-9_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8988-9_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9857-7

  • Online ISBN: 978-3-0348-8988-9

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