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Alpha-Keto Acid Dehydrogenase Complexes pp 131–138Cite as

Pyruvate dehydrogenase phosphatase

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Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Abstract

Four classes of protein serine/threonine phosphatases have been identified in eukaryotic cells on the basis of substrate specificities and sensitivity to activators and inhibitors (Cohen, 1989; Shenolikar and Nairn, 1991). Protein phosphatase 1 is sensitive to the thermostable proteins inhibitor 1 and inhibitor 2, and protein phosphatases 1 and 2A are sensitive to okadaic acid. Protein phosphatase 2B is Ca2+/calmodulin-regulated and protein phosphatase 2C is Mg2+-dependent. The protein serine/threonine phosphatases of known sequence comprise two distinct gene families, a major family that includes protein phosphatases 1, 2A, and 2B and isoforms thereof, and a smaller family that includes protein phosphatase 2C and pyruvate dehydrogenase (PDH) phosphatase.

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Authors and Affiliations

  1. Biochemical Institute and Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX, 78712, USA

    L. J. Reed, J. E. Lawson, X.-D. Niu & J. Yan

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  1. L. J. Reed
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  2. J. E. Lawson
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  3. X.-D. Niu
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  4. J. Yan
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Editor information

Editors and Affiliations

  1. Department of Biochemistry School of Medicine and Biomedical Sciences, State University of New York, 140 Farber Hall 3435 Main Street, 14214, Buffalo, New York, USA

    Mulchand S. Patel

  2. Department of Biochemistry, Kansas State University, 104 Willard Hall, 66506, Manhattan, KS, USA

    Thomas E. Roche

  3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, 46202, Indianapolis, IN, USA

    Robert A. Harris

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Reed, L.J., Lawson, J.E., Niu, XD., Yan, J. (1996). Pyruvate dehydrogenase phosphatase. In: Patel, M.S., Roche, T.E., Harris, R.A. (eds) Alpha-Keto Acid Dehydrogenase Complexes. MCBU Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8981-0_9

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  • DOI: https://doi.org/10.1007/978-3-0348-8981-0_9

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9853-9

  • Online ISBN: 978-3-0348-8981-0

  • eBook Packages: Springer Book Archive

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