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Alpha-Keto Acid Dehydrogenase Complexes pp 53–70Cite as

Lipoamide dehydrogenase

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Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Summary

In this review the structure and function of the lipoamide dehydrogenase component of the keto acid dehydrogenase complexes is discussed. Three structural models are available and in recent years many new genes have been sequenced and expressed. Unsolved is the role that many non-complex-bound lipoamide dehydrogenases play in metabolism and the physiological function of free lipoic acid. Central in catalysis is the problem of stabilization of the 2-electron reduced enzyme. Mutagenesis studies and the use of a modified flavin cofactor revealed the various factors involved in this stabilization in which also the core component of the complex has a function.

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Authors and Affiliations

  1. Department of Biochemistry, Agricultural University, Dreijenlaan 3, NL-6703 HA, Wageningen, The Netherlands

    A. de Kok & W. J. H. van Berkel

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  1. A. de Kok
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  2. W. J. H. van Berkel
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Editors and Affiliations

  1. Department of Biochemistry School of Medicine and Biomedical Sciences, State University of New York, 140 Farber Hall 3435 Main Street, 14214, Buffalo, New York, USA

    Mulchand S. Patel

  2. Department of Biochemistry, Kansas State University, 104 Willard Hall, 66506, Manhattan, KS, USA

    Thomas E. Roche

  3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, 46202, Indianapolis, IN, USA

    Robert A. Harris

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© 1996 Birkhäuser Verlag Basel/Switzerland

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de Kok, A., van Berkel, W.J.H. (1996). Lipoamide dehydrogenase. In: Patel, M.S., Roche, T.E., Harris, R.A. (eds) Alpha-Keto Acid Dehydrogenase Complexes. MCBU Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8981-0_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8981-0_4

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9853-9

  • Online ISBN: 978-3-0348-8981-0

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