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Hormonal and nutritional modulation of PDHC activity status

  • Chapter
Alpha-Keto Acid Dehydrogenase Complexes

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Abstract

In animals, glucose oxidation is decreased by starvation and diabetes (reviewed by Randle, 1986; Patel and Roche, 1990; Sugden and Holness, 1994). As well as short-term effects of starvation and diabetes to suppress glucose oxidation, long-term regulatory mechanisms impose an upper limit on the overall capacity for glucose oxidation and introduce latency of reactivation of glucose oxidation when a high-carbohydrate, low-fat meal is provided, or when insulin is administered after prolonged starvation. These characteristics of whole-body glucose oxidation reflect the activity and regulatory characteristics of the mitochondrial pyruvate dehydrogenase holocomplex (PDHC), which catalyses the oxidative decarboxylation of pyruvate to acetyl CoA. This chapter will review the regulation of PDHC by hormones and nutrients within the context of the competition between fatty acids (FA) and glucose as oxidative substrates.

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Author information

Authors and Affiliations

  1. Department of Biochemistry (Basic Medical Sciences), Queen Mary and Westfield College, Mile End Road, London, E1 4NS, UK

    M. C. Sugden & M. J. Holness

Authors
  1. M. C. Sugden
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  2. M. J. Holness
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Editor information

Editors and Affiliations

  1. Department of Biochemistry School of Medicine and Biomedical Sciences, State University of New York, 140 Farber Hall 3435 Main Street, 14214, Buffalo, New York, USA

    Mulchand S. Patel

  2. Department of Biochemistry, Kansas State University, 104 Willard Hall, 66506, Manhattan, KS, USA

    Thomas E. Roche

  3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, 46202, Indianapolis, IN, USA

    Robert A. Harris

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Sugden, M.C., Holness, M.J. (1996). Hormonal and nutritional modulation of PDHC activity status. In: Patel, M.S., Roche, T.E., Harris, R.A. (eds) Alpha-Keto Acid Dehydrogenase Complexes. MCBU Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8981-0_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8981-0_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9853-9

  • Online ISBN: 978-3-0348-8981-0

  • eBook Packages: Springer Book Archive

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