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Clinical and Biological Basis of Lung Cancer Prevention pp 157–167Cite as

Birkhäuser

DNA Methylation Changes in Lung Cancer

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Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Summary

Recent evidence has suggested a role for DNA methylation changes and for DNA (cytosine 5-) methyltransferase in some aspect of tumor development. Limited data are currently available related to changes in the methylation process in lung cancer. Using a novel two-dimensional genome scanning approach to detect gene dosage alterations in tumors, we have identified loci that exhibited hypermethylation and others that exhibited hypomethylation in lung adenocarcinoma. The data suggest that some of the methylation changes observed are unlikely to be due to methylation errors. Full implementation of the genome scanning approach will probably uncover a large number of loci affected by methylation change in lung carcinogenesis.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA

    Samir M. Hanash, Rork Kuick, Katharina Wimmer, Didier H. Thoraval & Barbara Lamb

  2. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Bruce Richardson

  3. Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA

    Yoshihiro Nambu & David G. Beer

Authors
  1. Samir M. Hanash
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  2. Bruce Richardson
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  3. Rork Kuick
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  4. Katharina Wimmer
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  5. Didier H. Thoraval
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  6. Barbara Lamb
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  7. Yoshihiro Nambu
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  8. David G. Beer
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Editor information

Editors and Affiliations

  1. Hôpital de Brabois Service de Pneumologie A, Centre Hospitalier Universitaire de Nancy, 54511, Vandoeuvre-lès-Nancy, France

    Yves Martinet

  2. The Finsen Center Department of Oncology 5074, Copenhagen University Hospital Rigshospitalet, DK-2100, Copenhagen, Denmark

    Fred R. Hirsch

  3. Unité de Recherche de Physipathologie Respiratoire, INSERM U14, C.O. No 10, 54511, Vandoeuvre-lès-Nancy, France

    Nadine Martinet

  4. Service d’Anatomie Pathologique, Centre Hospitalier Universitaire de Nancy Hôpital Central, 54035, Nancy, France

    Jean-Michel Vignaud

  5. National Cancer Institute / National Institutes of Health, Division of Clinical Sciences / Medicine Branch Cell and Cancer Biology Department, Rockville, MD, 20850-3300, USA

    James L. Mulshine

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© 1998 Springer Basel AG

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Hanash, S.M. et al. (1998). DNA Methylation Changes in Lung Cancer. In: Martinet, Y., Hirsch, F.R., Martinet, N., Vignaud, JM., Mulshine, J.L. (eds) Clinical and Biological Basis of Lung Cancer Prevention. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8924-7_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8924-7_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9829-4

  • Online ISBN: 978-3-0348-8924-7

  • eBook Packages: Springer Book Archive

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