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Airway Mucin Genes and Gene Products

  • Chapter
Airway Mucus: Basic Mechanisms and Clinical Perspectives

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

Abstract

MUC genes and their MUC gene products have been the subject of several reviews in the last few years [1-4] as expected in a field where the molec­ular tools to address fundamental and disease-related questions are becom­ing available. A description and analysis of human mucin genes MUC/through MUC7 and of porcine canine murine rat and bovine mucin geneswere published in 1995 [4]. In this review, we have focused on MUC genes and gene products expressed in human airways and highlighted our current limited understanding of their role in health and disease. We have summarized the available information on MUC8 and updated the available information on MUC5/5AC, MUC5B and animal mucin genes.

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Authors and Affiliations

  1. Center for Molecular Mechanisms of Diseases, Departments of Pediatrics and of Biochemistry and Molecular Biology, Children’s Research Institute, Children’s National Medical Center, Washington DC, USA

    Mary Callaghan Rose

  2. Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, Arizona, USA

    Sandra J. Gendler

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  1. Mary Callaghan Rose
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Editors and Affiliations

  1. Department of Thoracic Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, England

    Duncan F. Rogers

  2. Department of Pharmacy, University of Brighton, Lewes Road, Brighton, BN2 4GJ, England

    Michael I. Lethem

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Rose, M.C., Gendler, S.J. (1997). Airway Mucin Genes and Gene Products. In: Rogers, D.F., Lethem, M.I. (eds) Airway Mucus: Basic Mechanisms and Clinical Perspectives. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8874-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8874-5_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9809-6

  • Online ISBN: 978-3-0348-8874-5

  • eBook Packages: Springer Book Archive

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