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Experimental Induction of Goblet Cell Hyperplasia In Vivo

  • Chapter
Airway Mucus: Basic Mechanisms and Clinical Perspectives

Part of the book series: Respiratory Pharmacology and Pharmacotherapy ((RPP))

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Abstract

Experimental animal models have contributed to our understanding of the aetiology, pathogenesis and potential for therapy of many human diseases. Several human airway conditions, such as chronic bronchitis, asthma, cystic fibrosis and bronchiectasis have mucus-hypersecretion as a common feature [1-15]. The major sources of airway mucus are (1) luminal mucosubstance present on surface epithelium whose cellular source is presently unclear [16-19], (2) the surface epithelial mucous cell, also called the “goblet cell”, and (3) the “mucous cells” of the submucosal glands [20-26]. The serous cells of the submucosal glands may also contribute to the glycoprotein component of mucus and in addition may secrete glycosaminoglycan, a small molecular weight antiprotease [27] and the secretory piece component of IgA. As we shall see, there is increasing evidence that other cell types including the ciliated cell may also contribute to the pool of airway mucus.

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  1. Lung Pathology Unit, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK

    Dechun Li & Peter K. Jeffery

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  1. Dechun Li
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  1. Department of Thoracic Medicine National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, England

    Duncan F. Rogers

  2. Department of Pharmacy, University of Brighton, Lewes Road, Brighton, BN2 4GJ, England

    Michael I. Lethem

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Li, D., Jeffery, P.K. (1997). Experimental Induction of Goblet Cell Hyperplasia In Vivo . In: Rogers, D.F., Lethem, M.I. (eds) Airway Mucus: Basic Mechanisms and Clinical Perspectives. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8874-5_10

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