Dipyrone in pain management
Dipyrone and paracetamol represent the small family of non-acidic, non-opioid analgesics which do not exhibit anti-inflammatory activity. The analgesic efficacy of dipyrone is broad and comparable to that of the non-steroidal anti-inflammatory drugs (NSAIDs) and tramadol. Because dipyrone is a weak cyclo-oxygenase inhibitor, its use is not associated with gastric irritation, an important advantage for long-term administration. Uniquely, dipyrone has intrinsic spasmolytic activity. This makes the drug particularly useful in renal colic pain.