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The role of apoptosis in neurodegenerative diseases

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Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

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Abstract

Apoptosis is a single word that describes the complex contortions of the membrane and organelles of a cell as it goes through the process of programmed cell death. During this process, the cell activates an intrinsic suicide programme and systematically destroys itself. Apoptosis occurs rapidly, usually taking between a few minutes and a couple of hours, and can be fascinating to watch in real time down a microscope. The following series of events can be observed: the cell surface begins to bleb and express pro-phagocytic signals, and the cell then separates from its neighbours. The nucleus also goes through a characteristic pattern of morphological changes as it commits genetic suicide: the chromatin condenses and is specifically cleaved to fragments of DNA (Fig. l).The whole apoptotic cell then fragments into membrane-bound vesicles that are rapidly and cleanly disposed of by phagocytosis, so that there is minimal damage to the surrounding tissue.

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Hajimohamadreza, I., Treherne, J.M. (1997). The role of apoptosis in neurodegenerative diseases. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, vol 48. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8861-5_3

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