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Assessment of surfactant function

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Methods in Pulmonary Research

Abstract

The film of surface active material (“surfactant”) that coats the terminal airspaces and conducting airways is of vital physiological importance. It prevents end-expiratory alveolar collapse by reducing the contractile force of surface tension at low lung volumes, and furthermore constitutes a barrier involved in the pulmonary defence system. Lung surfactant has a crucial role in the process of neonatal adaptation by lowering the alveolar opening pressure. It also stabilizes the newly aerated alveoli during the first ventilatory cycles, allowing effective gas exchange soon after birth. Inadequate supply of surfactant material in the lungs of a premature newborn baby is characteristically associated with a type of respiratory failure known as respiratory distress syndrome (RDS), a major cause of neonatal morbidity and mortality [1].

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References

  1. Walther FJ and Taeusch HW (1992) Pathophysiology of Neonatal Surfactant Insufficiency: Clinical Aspects. In: Pulmonary Surfactant. From Molecular Biology to Clinical Practice, Robertson B, van Golde LMG and Batenburg JJ (eds), p. 485, Elsevier Amsterdam

    Google Scholar 

  2. Chung JB, Shanks PC, Hanneman RE and Frances EI (1990) Colloids Surfaces 43: 223

    Article  CAS  Google Scholar 

  3. Exerowa D, Lalchev Z, Marinow B and Orgnyanov K (1986) Langmuir 2: 664

    Article  Google Scholar 

  4. Langmuir I (1917) J. Am. Chem. Soc. 39: 1848

    Article  CAS  Google Scholar 

  5. Pockels A (1891) Nature 43: 437

    Google Scholar 

  6. Adamson AW (1990) Physical Chemistry of Surfaces (Fifth Edition). John Wiley and Sons New York

    Google Scholar 

  7. Clements JA (1957) Proc Soc. Exp. Biol. Med. 95: 170

    PubMed  CAS  Google Scholar 

  8. Adam NK (1968) The Physics and Chemistry of Surfaces. Dover Publications, New York

    Google Scholar 

  9. Gaines GL (1972) J. Colloid Interface Sci. 60: 210

    Article  Google Scholar 

  10. Scarpelli EM (1968) The Surfactant System of the Lung. Lea and Febiger, Philadelphia

    Google Scholar 

  11. Hildebran JN, Goerke J and Clements JA (1979) J. Appl. Physiol. 47: 604

    PubMed  CAS  Google Scholar 

  12. Notter RH (1984) Surface Chemistry of Pulmonary Surfactant: The Role of Individual Components. In: Pulmonary Surfactant,Robertson B, Van Golde LMG and Batenburg JJ (eds), p. 17, Elsevier Amsterdam

    Google Scholar 

  13. Munden JW and Swarbrick J (1973) J. Colloid Interface Sci. 42: 657

    Article  CAS  Google Scholar 

  14. Boonman A, Machiels FHJ, Suik AFM and Egberts J (1987) J. Colloid Interface Sci. 120: 452

    Article  Google Scholar 

  15. Clements JA, Hustead RF, Johnson RP and Gribetz I (1961) J. Appl. Physiol. 16: 444

    PubMed  CAS  Google Scholar 

  16. Schoedel W, Slama H and Hansen E (1971) Pfluegers Arch. 322: 336

    Article  CAS  Google Scholar 

  17. Qiu R and MacDonald RC (1994) Rev. Sci. Instr. 62: 500

    Article  Google Scholar 

  18. Goerke J and Gonzales J (1971) J. Appl. Physiol. 51: 1108

    Google Scholar 

  19. Notter RH and Morrow PE (1975) Annals Biomed. Engin. 3: 119

    Article  CAS  Google Scholar 

  20. Schürch FS (1975) Thesis, The University of Western Ontario

    Google Scholar 

  21. Slama H, Schoedel W and Hansen E (1971) Pfluegers Arch. 322: 355

    Article  CAS  Google Scholar 

  22. Slama H, Schoedel W and Hansen E (1973) Respir. Physiol. 19: 233

    Article  PubMed  CAS  Google Scholar 

  23. Enhorning G (1977) J. Appl. Physiol. 43: 198

    PubMed  CAS  Google Scholar 

  24. Possmayer F (1991) Biophysical Activity of Pulmonary Surfactant. In: Fetal and Neonatal Physiology,Polin RA and Fox WW (eds), p. 459, WB Saunders Philadelphia

    Google Scholar 

  25. Putz G, Goerke J, Taeusch HW and Clements JA (1994) J. Appl. Physiol. 76: 1425

    PubMed  CAS  Google Scholar 

  26. Schürch S, Bachofen H, Goerke J and Possmayer F (1989) J. Appl. Physiol. 67: 2389

    PubMed  Google Scholar 

  27. Schürch S, Bachofen H, Goerke J and Green F (1992) Biochim. Biophys. Acta 1103: 127

    Article  PubMed  Google Scholar 

  28. Putz G, Schürch S, Goerke J and Clements JA (1994) J. Appl. Physiol. 76: 2389

    Google Scholar 

  29. Schoel WM, Schürch S and Goerke J (1994) Biochim. Biophys. Acta 1200: 286

    Article  Google Scholar 

  30. Rotenberg YL, Boruvka L and Neumann AW (1983) J. Colloid Interface Sci. 93: 169

    Article  CAS  Google Scholar 

  31. Schürch S, Possmayer F, Cheng S and Cockshutt AM (1992) Am. J. Physiol. 263: L210

    PubMed  Google Scholar 

  32. Pattle RE (1955) Nature 175: 1125

    Article  PubMed  CAS  Google Scholar 

  33. Pattle RE (1958) Proc. Roy. Soc. B 148: 217

    Google Scholar 

  34. Pattle RE (1976) The Lung Surfactant in the Evolutionary Tree. In: Respiration of Amphibious Vertebrates, Hughes GM (ed.), Assessment of surfactant function p. 234, Academic Press New York

    Google Scholar 

  35. Pattle RE, Kratzing CC, Parkinson CE et al. (1979) Br. J. Obstet. Gynaecol. 86: 615

    Article  PubMed  CAS  Google Scholar 

  36. Chida S (1995) A Stable Microbubble Test for Antenatal and Early Neonatal Diagnosis of Surfactant Deficiency. In: Surfactant Therapy for Lung Disease,Robertson B and Tauesch HW (eds), p. 107, Marcel Dekker New York

    Google Scholar 

  37. Chida S, Fujiwara T, Takahashi A, Kanehama S and Kaneko J (1991) Acta Paediatr. Jpn. 33: 15

    Article  PubMed  CAS  Google Scholar 

  38. Chida S and Fujiwara T (1993) Eur. J. Pediatr. 152: 148

    Article  PubMed  CAS  Google Scholar 

  39. Chida S, Fujiwara T, Konishi M, Takahashi H and Sasaki M (1993) Eur. J. Pediatr. 152: 148

    Article  PubMed  CAS  Google Scholar 

  40. Berggren P, Eklind J, Linderholm B and Robertson B (1992) Biol. Neonate 61(suppl 1): 15

    PubMed  CAS  Google Scholar 

  41. Berggren P and Linderholm B (1996) Biol. Neonate 69: 133

    Article  Google Scholar 

  42. Epstein PS and Plesset MS (1950) J. Chem. Phys. 18: 1505

    Article  CAS  Google Scholar 

  43. Schürch S, Schürch D, Curstedt T and Robertson B (1994) J. Appl. Physiol. 77: 974

    PubMed  Google Scholar 

  44. Schürch S, Qanbar R, Bachofen H and Possmayer F (1995) Biol. Neonate 67(suppl 1): 61

    PubMed  Google Scholar 

  45. Schürch S, Wallace JA, Wilkinson MH and McIver DJL (1989) Protein Adsorption at Air Water Interfaces Stabilised by Phospholipids Related to Pulmonary Surfactant: Microbubbles as an Ultrasonic Contrast Agent. In: Surfactants in Solution,Mittal KL (ed.), Plenum Press New York

    Google Scholar 

  46. Overbeek JTG (1971) Colloid and Surface Chemistry Study Guide (third printing, 1981), Lectures, Massachusetts Institute of Technology, Center for Advanced Engineering Study, MIT

    Google Scholar 

  47. Chang C-H and Franses EI (1995) Colloids Surfaces 100: 1

    Article  CAS  Google Scholar 

  48. Andrade JD (1985) Principles of Protein Adsorption. In: Surface and Interfacial Aspects of Biomedical Polymers, Andrade JD (ed.), p. 1, Plenum Press New York

    Chapter  Google Scholar 

  49. Davies JT and Rideal EK (1963) Interfacial Phenomena, Academic Press New York

    Google Scholar 

  50. Curstedt T, Jörnvall H, Robertson B, Bergman T and Berggren P (1987) Eur. J. Biochem. 168: 255

    Article  PubMed  CAS  Google Scholar 

  51. Hawgood S, Benson BJ, Schilling J, Damm D and Clements JA (1987) Proc. Natl. Acad. Sci. USA 84: 66

    Article  PubMed  CAS  Google Scholar 

  52. Yu S-H and Possmayer F (1990) Biochim. Biophys. Acta 1046: 233

    Article  PubMed  CAS  Google Scholar 

  53. Qanbar R, Cheng S, Possmayer F and Schürch S (1996) Am. J. Physiol. 271: L572

    PubMed  CAS  Google Scholar 

  54. Damodaran S and Song KB (1989) Adsorption of Protein of the Air-Water Interface: Role of Protein Conformation. In: Surfactants in Solution,Mittal KL (ed.), p. 391, Plenum Press New York

    Google Scholar 

  55. Graham DE and Phillips MC (1979) J. Colloid Interface Sci. 70: 415

    Article  CAS  Google Scholar 

  56. Birdi KS (1973) J. Colloid Interface Sci. 43: 545

    Article  CAS  Google Scholar 

  57. Weibel ER and Gil J (1968) Respir. Physiol. 4: 42

    Article  PubMed  CAS  Google Scholar 

  58. Gil J and Weibel ER (1969/70) Respir. Physiol. 8: 13

    Article  PubMed  CAS  Google Scholar 

  59. Schürch S and Bachofen H (1995) Biophysical Aspects in the Design of a Therapeutic Surfactant. In: Surfactant Therapy for Lung Disease, Robertson B and Taeusch HW (eds), p. 3, Marcel Dekker New York

    Google Scholar 

  60. Grossmann G and Robertson B (1975) Acta Paediatr. Scand. 64: 7

    Article  PubMed  CAS  Google Scholar 

  61. Ueda S, Izumi T, Ishii N, Matsumoto S, Hayashi K and Okayasu M (1982) J. Jpn. Med. Soc. Biol. Interface 13: 26

    Google Scholar 

  62. Clements JA (1977) Am. Rev. Respir. Dis. 115: 67

    PubMed  CAS  Google Scholar 

  63. Gaines GL (1966) Insoluble Monolayers at Liquid-Gas Interfaces. Interscience Publishers, John Wiley and Sons New York

    Google Scholar 

  64. Grotberg JB (1994) J. Fluid Mech. 26: 529

    Article  Google Scholar 

  65. Grotberg JB, Halpern D and Jensen OE (1995) J. Appl. Physiol. 78: 750

    PubMed  CAS  Google Scholar 

  66. King RJ and Clements JA (1972) Am. J. Physiol. 223: 715

    PubMed  Google Scholar 

  67. Putz G, Goerke J and Clements JA (1994) J. Appl. Physiol. 77: 597

    PubMed  CAS  Google Scholar 

  68. Joos P and Van Hunsel J (1985) J. Colloid Interface Sci. 106: 161

    Article  CAS  Google Scholar 

  69. Gaver DP and Grotberg JB (1992) J. Fluid Mech. 235: 399

    Article  CAS  Google Scholar 

  70. Jensen OE and Grotberg JB (1992) J. Fluid Mech. 240: 259

    Article  CAS  Google Scholar 

  71. Jensen OE, Halpern D and Grotberg JB (1994) Chem. Engin. Sci. 49: 1107

    Article  CAS  Google Scholar 

  72. Schürch S, Goerke J and Clements JA (1976) Proc. Natl. Acad. Sci. USA 73: 4698

    Article  PubMed  Google Scholar 

  73. Schürch S, Goerke J and Clements JA (1978) Proc. Natl. Acad. Sci. USA 75: 3417

    Article  PubMed  Google Scholar 

  74. Williams EJ (1959) Regression Analysis. John Wiley and Sons New York

    Google Scholar 

  75. Schürch S (1982) Respir. Physiol. 48: 339

    Article  PubMed  Google Scholar 

  76. Schürch S, Bachofen H and Weibel ER (1985) Respir. Physiol. 62: 31

    Article  PubMed  Google Scholar 

  77. Bachofen H, Schürch S, Urbinelli M and Weibel ER (1987) J. Appl. Physiol. 62: 1878

    PubMed  CAS  Google Scholar 

  78. Bastacky J, Lee CYC, Goerke J, Koushafar H, Yager D, Kenega L, Speed TP, Chen Y and Clements JA (1995) J. Appl. Physiol. 79: 1615

    PubMed  CAS  Google Scholar 

  79. von Neergaard K (1929) Z. Ges. Exp. Med. 66: 373

    Article  Google Scholar 

  80. Enhörning G and Robertson B (1972) Pediatrics 50: 58

    PubMed  Google Scholar 

  81. Fujiwara T and Robertson B (1992) Pharmacology of Exogenous Surfactant. In: Pulmonary Surfactant. From Molecular Biology to Clinical Practice, Robertson B, van Golde LMG and Batenburg JJ (eds), p. 561, Elsevier Amsterdam

    Google Scholar 

  82. Bermel MS, McBride JT and Notter RH (1984) Lung 162: 99

    Article  PubMed  CAS  Google Scholar 

  83. Hall SB, Venkitaraman AR, Whitsett JA, Holm BA and Notter RH (1992) Am. Rev. Respir. Dis. 145: 24

    Article  PubMed  CAS  Google Scholar 

  84. Kobayashi T, Li W-Z, Tashiro K, Takahashi R, Waseda Y, Yamamoto K and Suzuki Y (1996) J. Appl. Physiol. 80: 62

    PubMed  CAS  Google Scholar 

  85. Robertson B (1992) Animal Models of Neonatal Surfactant Dysfunction. In: Pulmonary Surfactant. From Molecular Biology to Clinical Practice, Robertson B, van Golde LMG and Batenburg JJ (eds), p. 459, Elsevier Amsterdam

    Google Scholar 

  86. Yukitake K, Brown CL, Schlueter MA, Clements JA and Hawgood S (1995) Pediatr. Res. 37: 21

    Article  PubMed  CAS  Google Scholar 

  87. Berggren P, Curstedt T, Grossmann G, Nilsson R and Robertson B (1985) Exp. Lung Res. 8: 29

    Article  PubMed  CAS  Google Scholar 

  88. Kobayashi T, Nitta K, Ganzuka M, Inui S, Grossmann G and Robertson B (1991) Pediatr. Res. 29: 353

    Article  PubMed  CAS  Google Scholar 

  89. Ikegami M, Berry D, Elkady T, Pettenazzo A, Seidner S and Jobe A (1987) J. Clin. Invest. 79: 1371

    Article  PubMed  CAS  Google Scholar 

  90. Sun B, Kobayashi T, Curstedt T, Grossmann G and Robertson B (1991) Eur. Respir. J. 4: 364

    PubMed  CAS  Google Scholar 

  91. Rider ED, Jobe AH, Ikegami M and Sun B (1992) J. Appl. Physiol. 73: 2089

    PubMed  CAS  Google Scholar 

  92. Rider ED, Ikegami M, Whitsett JA, Hull W, Absolom D and Jobe AH (1993) Am. Rev. Respir. Dis. 147: 669

    PubMed  CAS  Google Scholar 

  93. Noack G, Curstedt T, Grossmann G, Nilsson R and Robertson B (1990) Respiration 57: 1

    Article  PubMed  CAS  Google Scholar 

  94. Scherle W (1970) Mikroskopie 26: 57

    PubMed  CAS  Google Scholar 

  95. Robertson B, Berry D, Curstedt T, Grossmann G, Ikegami M, Jacobs H, Jobe A and Jones S (1985) Respir. Physiol. 61: 265

    Article  PubMed  CAS  Google Scholar 

  96. Anceschi MM, Robertson B, Broccucci L, Barbati A, Grossmann G, Hedenborg L, Lundberg E, Petrelli A, Zaccardo G and Cosmi EV (1990) Exp. Lung Res. 16: 593

    Article  PubMed  CAS  Google Scholar 

  97. Rigaut JP and Robertson B (1986) Pediatr. Pathol. 6: 11

    Article  PubMed  CAS  Google Scholar 

  98. Robertson B and Lachmann B (1988) Exp. Lung Res. 14: 279

    Article  PubMed  CAS  Google Scholar 

  99. Lachmann B, Robertson B and Vogel J (1980) Acta Anaesthesiol. Scand. 24: 231

    Article  PubMed  CAS  Google Scholar 

  100. Bambang Oetomo S, Reijngoud D-J, Ennema JJ, Okken A and Wildevuur ChRH (1988) Lung 166: 65

    Article  Google Scholar 

  101. Kobayashi T, Kataoka H, Ueda T, Murakami S, Takada Y and Kokubo M (1984) J. Appl. Physiol. 57: 995

    PubMed  CAS  Google Scholar 

  102. Segerer H, van Gelder W, Angenent FWM, van Woerkens LJPM, Curstedt T, Obladen M and Lachmann B (1993) Pediatr. Res. 34: 490

    Article  PubMed  CAS  Google Scholar 

  103. Berggren P, Lachmann B, Curstedt T, Grossmann G and Robertson B (1986) Acta Anaesthesiol. Scand. 30: 321

    Article  PubMed  CAS  Google Scholar 

  104. Sood SL, Balaraman V, Finn KC, Britton B, Uyehara CFT and Easa D (1996) Am. J. Respir. Crit. Care Med. 153: 820

    PubMed  CAS  Google Scholar 

  105. Häfner D, Germann PG and Hauschke (1994) Pulm. Pharmacol. 7: 319

    Article  PubMed  Google Scholar 

  106. Walther FJ (1995) Surfactant Therapy for Neonatal Lung Disorders Other than Respiratory Distress Syndrome. In: Surfactant Therapy for Lung Disease,Robertson B and Taeusch HW (eds), p. 461, Marcel Dekker New York

    Google Scholar 

  107. Günther A and Seeger W (1995) Resistance to Surfactant Inactivation. In: Surfactant Therapy for Lung Disease, Robertson B and Taeusch HW (eds), p. 269, Marcel Dekker New York

    Google Scholar 

  108. van Iwaarden F and van Golde LMG (1995) Pulmonary Surfactant and Lung Defense. Interactions of Surfactant Proteins with Phagocytic Cells and Pathogens. In: Surfactant Therapy for Lung Disease, Robertson B and Taeusch HW (eds), p. 75, Marcel Dekker New York

    Google Scholar 

  109. Cochrane CG and Revak SD (1991) Science 254: 566

    Article  PubMed  CAS  Google Scholar 

  110. Merritt TA, Amirkhanian JD, Helbock H, Halliwell B and Cross CE (1993) Biochem. J. 295: 19

    PubMed  CAS  Google Scholar 

  111. Robertson B (1995) Experimental Models for Evaluation of Exogenous Surfactants. In: Surfactant Therapy for Lung Disease, Robertson B and Taeusch HW (eds), p. 239, Marcel Dekker New York

    Google Scholar 

  112. Robertson B (1996) Arch. Dis. Child 75: F1

    Article  CAS  Google Scholar 

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Authors
  1. B. Robertson
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  2. S. Schürch
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Editors and Affiliations

  1. Department of Pulmonary Pharmacology, Forschungszentrum Borstel, Parkallee 22, D-23845, Borstel, Germany

    Stefan Uhlig

  2. Department of Physiology College of Medicine, University of Southern Alabama, Mobile, AL, 36688, USA

    Aubrey E. Taylor

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Robertson, B., Schürch, S. (1998). Assessment of surfactant function. In: Uhlig, S., Taylor, A.E. (eds) Methods in Pulmonary Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8855-4_14

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  • DOI: https://doi.org/10.1007/978-3-0348-8855-4_14

  • Publisher Name: Birkhäuser, Basel

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