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Primary cell cultures from fish in ecotoxicology

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Book cover Fish Ecotoxicology

Part of the book series: EXS ((EXS,volume 86))

Summary

Fish cell cultures from fish are used in studies on the fate and effects of xenobiotics at the cellular level. So far, special attention has been paid to primary cultures of hepatocytes. This cell type has been particularly useful for studies on biotransformation of xenobiotics. Among biotransformation enzymes, a number of studies have been devoted to cytochrome P4501A due to its inducibility by ecotoxicologically relevant pollutants. Biomarkers of DNA damage, i.e., DNA adducts and single strand breaks, have also been investigated. Furthermore, primary cultures of fish hepatocytes appear as promising models for studies on the effects of xenobiotics on critical steps of fish reproductive physiology. All the data are discussed in an ecotoxicological perspective.

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Author information

Authors and Affiliations

  1. Institut National de la Recherche Agronomique, Unité d’Écotoxicologie Aquatique, IFR 43, Campus de Beaulieu, F-35042, Rennes Cedex, France

    Gilles Monod

  2. Laboratoire des Sciences de l’Environnement, École Nationale des Travaux Publics de l’État, Rue Maurice Audin, F-69518, Vaulx-en Velin Cedex, France

    Alain Devaux

  3. Équipe d ‘Endocrinologie Moléculaire de la Reproduction, UPRES-A CNRS 6026, IFR 43, Campus de Beaulieu, F-35042, Rennes Cedex, France

    Yves Valotaire

  4. Laboratoire des Xénobiotiques, Institut National de la Recherche Agronomique, 180 chemin de Tournefeuille, BP 3, 31931, Toulouse Cedex, France

    Jean-Pierre Cravedi

Authors
  1. Gilles Monod
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  2. Alain Devaux
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  3. Yves Valotaire
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  4. Jean-Pierre Cravedi
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Editor information

Editors and Affiliations

  1. Department of Zoology I, Morphology/Ecology, University of Heidelberg, Im Neuenheimer Feld 230, D-69120, Heidelberg, Germany

    Thomas Braunbeck

  2. Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA

    David E. Hinton

  3. Department of Ecology and Evolution, Biologie-Campus, University of Frankfurt, Siesmayerstrasse, D-60054, Frankfurt, Germany

    Bruno Streit

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© 1998 Springer Basel AG

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Monod, G., Devaux, A., Valotaire, Y., Cravedi, JP. (1998). Primary cell cultures from fish in ecotoxicology. In: Braunbeck, T., Hinton, D.E., Streit, B. (eds) Fish Ecotoxicology. EXS, vol 86. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8853-0_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8853-0_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9802-7

  • Online ISBN: 978-3-0348-8853-0

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