Metallothionein: Molecular evolution and classification

  • Pierre-Alain Binz
  • Jeremias H. R. Kägi
Part of the Advances in Life Sciences book series (ALS)


The nomenclature system for metallothionein was first adopted in 1978 [1] and extended in 1985 by introducing a subdivision of MTs into three classes [2]. According to this convention class I includes all proteinaceous MTs with locations of Cys closely related to those in the mammalian forms. Class II comprises proteinaceous MTs which lack this property. Class III subsumes metallopolyisopeptides containing gammaglutamyl-cysteinyl units resembling in their features proteinaceous MTs.


Molecular Evolution Sequence Pattern Nomenclature System Stone Loach Convention Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. [1]
    Kägi JHR, Kojima Y (1979) Nomenclature of metallothionein: a proposal. Exp Suppl 34: 141–142.Google Scholar
  2. [2]
    Fowler BA, Hildebrand CE, Kojima Y, Webb M (1987) Nomenclature of metallothionein. Exp Suppl 52: 19–22.Google Scholar
  3. [3]
    Bairoch A, Apweiler R (1996) The SWISS-PROT protein sequence data bank and its new supplement TrEMBL. Nucl Acid Res 24: 21–25.CrossRefGoogle Scholar
  4. [4]
    Felsenstein J (1988) Phylogenies from molecular sequences: inference and reliability Annu Rev Gent 22: 521–565 b Felsenstein J (1993) PHYLIP (Phylogeny Inference Package) version 3.5c. Distributed by the author. Department of Genetics, University of Washington, Seattle.Google Scholar
  5. [5]
    Kojima Y, Binz P-A, Kägi JHR (1997) Nomenclature of metallothionein: Proposal for a revision. This volume.Google Scholar
  6. [6]
    Kägi JHR, Kojima Y (1987) Chemistry and Biochemistry of metallothionein. Exp Suppl 52: 25–61.Google Scholar
  7. [7]
    Binz P-A (1996) Metallothioneins: studies on molecular evolution and on the spectroscopic properties of its metal thiolate clusters PhD thesis, University of Zürich, Switzerland.Google Scholar

Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Pierre-Alain Binz
    • 1
  • Jeremias H. R. Kägi
    • 2
  1. 1.Laboratoire Central de Chimie CliniqueHôpital Cantonal UniversitaireGeneve 14Switzerland
  2. 2.Biochemisches Institut der Universität ZürichZürichSwitzerland

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