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Progress in Drug Research pp 107–133Cite as

Birkhäuser

Endothelium-derived hyperpolarizing factor — a critical appraisal

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Part of the book series: Progress in Drug Research ((PDR,volume 50))

Summary

Endothelium-derived hyperpolarizing factor is defined as that substance which produces vascular smooth muscle hyperpolarization which cannot be explained by nitric oxide or by a cyclo-oxygenase product such as prostacyclin. The possibility that the factor is an epoxyeicosatrienoic acid or a cannabinoid agonist such as anandamide continues to be investigated, but definitive evidence in favour of either is lacking. The sensitivity of EDHF-mediated responses to charybdotoxin, to apamin or to mixtures of these two toxins may indicate the opening of more than one smooth muscle K-chan-nel, but the possibility that these are located on the vascular endothelium is discussed.

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  1. School of Biological Sciences, G38 Stopford Building University of Manchester, Manchester, M13 9PT, UK

    Gillian Edwards & Arthur H. Weston

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    Ernst Jucker

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    Ernst Jucker

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Edwards, G., Weston, A.H. (1998). Endothelium-derived hyperpolarizing factor — a critical appraisal. In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 50. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8833-2_2

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