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Role of T cells in arthritis: Lessons from animal models

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T Cells in Arthritis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Rheumatoid Arthritis (RA) is a systemic disease of unknown etiology, with the main manifestation being chronic inflammation in multiple joints. In many patients the arthritis is characterized by exacerbations and remissions. Current theories of the pathogenesis of the chronic arthritis include a sustained immune reaction directed at unknown exogenous agents that localize to the joints or articular autoantigens such as cartilage matrix molecules. In addition, chronicity might be linked to a deranged “tumor like” behaviour of the synovial tissue cells of RA patients, including macrophages and synovial fibroblasts. These cells show an aggressive phenotype and prolonged growth in culture, without an apparent need for further stimuli. It might be argued that the underlying trigger is co-isolated with the cells, still being present in the culture and hence creating a seemingly autonomous activation. In that sense, viruses may be likely candidates.

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Authors and Affiliations

  1. Dept. of Rheumatology, University Hospital Nijmegen, Nijmegen, HB, NL-6500 HB, The Netherlands

    Wim B. van den Berg

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  1. Wim B. van den Berg
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Editors and Affiliations

  1. Departments of Immunology and Rheumatology Hôpital Edouard Herriot, University Claude Bernard, Lyon Cedex 03, F-69437, France

    Pierre Miossec

  2. Division of Rheumatology, UCSD School of Medicine, 9500 Gilman Drive, San Diego, CA, 92093-0656, USA

    Gary S. Firestein

  3. Department of Rheumatology, University Hospital Nijmegen, Geert Grooteplein 8, Nijmegen, NL-6525, The Netherlands

    Wim B. van den Berg

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van den Berg, W.B. (1998). Role of T cells in arthritis: Lessons from animal models. In: Miossec, P., Firestein, G.S., van den Berg, W.B. (eds) T Cells in Arthritis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8823-3_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8823-3_4

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