Abstract
11 patients with liver neoplasms (9 HCC,1 CCC,1multiple breast cancer metastases (BCM)) were treated by transarterial I-131-Lipiodol.CT and SPECT showed pronounced I-131-Lipiodol accumulation in the tumor tissue in all cases. In 2 HCC a significant reduction of tumor size was achieved. Of the patients with big tumor mass, 5 (4 HCC, 1 CCC) had stable disease, and 2 HCC were progressive. 1 patient died. The BCM proved significant reduction in number and size. 18-FDG-PET and CT controls showed in part different results with pretherapeutic PET proving high interindividual variability in tumor activity. Side effects were tolerabel.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
London W. Primary hepatocellular carcinoma — etiology,pathogenesis and prevention. Hum Pathol 1981; 12: 1085–1097.
Maraj R, Kew MC, Hyslop RJ. Resectability rate of hepatocellular carcinoma in rural southern Africans. Br J Surg 1988; 75: 335–338.
Groupe dé;etude et de traitement du carcinome hepatocellulaire. A comparison of Lipiodol chemoembolisation and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 1995; 332: 1256–1261.
Livraghi T, Bolondi L, Lazzaroni S et al. Percutaneous ethanol injection in the treatment of hepatocellular carcinoma in cirrhosis: a study on 207 patients. Cancer 1992; 69: 925–929.
Bretagne JF, Raoul XL, Bourguet P et al. Hepatic artery injection of I-131-labeled Lipiodol. Part 2: Preliminary results of therapeutic use in patients with hepatocellular carcinoma and liver metastases. Radiology 1988; 168: 547–550.
Raoul JL, Guyader D, Bretagne JF et al. Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: intra-arterial iodine-131-iodized oil versus medical support. J Nucl Med 1994; 35: 1782–1787.
Leung WT, Lau WY, Ho S et al. Selective internal radiation therapy with intra-arterial Iodine-131-Lipiodol in inoperable hepatocellular carcinoma. J Nucl Med 1994; 35: 1313–1318.
Novell R, Hilson A and Hobbs K. Ablation of recurrent primary liver cancer using 13-lipiodol. Postgrad Med J 1991; 67: 393–395.
Schild HH, Kutzner J. Intraarterielle Applikation von Radionukliden. In: Interventionelle Radiologie. Günther RW, Thelen M, editors. Stuttgart New York: Thieme, 1996: 336–339.
Kobayashi H, Hidaka H, Kajiya Y et al. Treatment of hepatocellular carcinoma by transarterial injection of anticancer agents in iodized oil suspension or of radioactive iodized oil solution. Acta Radiol [Diagn] 1986; 27: 139–147.
Yoo HS, Lee JT, Kim KW et al. Nodular hepatocellular carcinoma. Treatment with subsegmental intraarterial injection of iodine-131-labeled oil. Cancer 1991; 68: 1878–1884.
Raoul JL, Bourguet P, Bretagne JF et al. Hepatic artery injection of I-131-labeled Lipiodol. Part 1: Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology 1988; 168: 541–545.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer Basel AG
About this paper
Cite this paper
Risse, J.H., Grünwald, F., Strunk, H., Bultmann, T., Biersack, H.J. (1999). I-131-Lipiodol Therapy in Liver Neoplasms. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_9
Download citation
DOI: https://doi.org/10.1007/978-3-0348-8782-3_9
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-9772-3
Online ISBN: 978-3-0348-8782-3
eBook Packages: Springer Book Archive