Abstract
The aims of this preliminary pilot study were: to validate the gammascintigraphic method (pharmacoscintigraphy) with the new formulation; to generate some preliminary data regarding the transit time and disintegration behaviour of the new oral delivery placebo-tablets. Four volunteers received 2 mg of 153Sm2O3 by oral route, in one mesalazine placebo tablet. 153Sm oxide, obtained by means of neutron irradiation after a normal manifacturing procedure, is a γ-emitter of E-103 Kev, with tl/2 of 46,8 h, not adsorbed from G.I tract. 153Sm — SCAN was performed at 5,30 min. and 1, 1,5, 2,5, 3, 4, 5, 5, 7, 8, 10, 24 h after the dose. Time of disintegration in the colon varied from 5 to 8 h. Excellent imaging was obtained with very low radioactivity exposure (50 mRad). The “clock” release formulation achieved its target in most of subjects.
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Palumbo, R., Palumbo, B., Cardinali, L., Bonaca, S., Hartwig, J., Rastelli, C. (1999). Pharmacoscintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker. In: Bergmann, H., Köhn, H., Sinzinger, H. (eds) Radioactive Isotopes in Clinical Medicine and Research XXIII. Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8782-3_17
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DOI: https://doi.org/10.1007/978-3-0348-8782-3_17
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