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Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain

  • Z. T. Krasznai
  • L. Balkay
  • T. Márián
  • M. Emri
  • F. Németh
  • L. Trón
Conference paper
Part of the Advances in Pharmacological Sciences book series (APS)

Abstract

In vivo glucose metabolism of the brain was examined using the [18F] fluoro-deoxy-D- glucose (FDG) analogue of the glucose. A relatively high number (20–25) of volumes of interest (VOI) were defined on the PET images. Data of the kinetic studies belonging to these VOI-s were evaluated using the standard uptake value (SUV) method, or calculating glucose metabolic rate (GMR) applying Patlak analysis (PA); and three-compartment model with nonlinear regression (TCM). Correlation of data for all pairs of calculated parameters showed that accurate determination of glucose utilisation in anatomic regions of white matter and those located next to large blood vessels require application of the three-compartment tracer kinetic model calculations with no simplifying assumptions.

Keywords

Standard Uptake Value Cereb Blood Flow Large Blood Vessel Vascular Compartment Glucose Metabolic Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Z. T. Krasznai
    • 1
    • 2
  • L. Balkay
    • 1
    • 2
  • T. Márián
    • 1
    • 2
  • M. Emri
    • 1
    • 2
  • F. Németh
    • 1
    • 2
  • L. Trón
    • 1
    • 2
  1. 1.PET Centre, University Medical School DebrecenDebrecenHungary
  2. 2.PET Study Group of the Hungarian Academy of SciencesDebrecenHungary

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