Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain
In vivo glucose metabolism of the brain was examined using the [18F] fluoro-deoxy-D- glucose (FDG) analogue of the glucose. A relatively high number (20–25) of volumes of interest (VOI) were defined on the PET images. Data of the kinetic studies belonging to these VOI-s were evaluated using the standard uptake value (SUV) method, or calculating glucose metabolic rate (GMR) applying Patlak analysis (PA); and three-compartment model with nonlinear regression (TCM). Correlation of data for all pairs of calculated parameters showed that accurate determination of glucose utilisation in anatomic regions of white matter and those located next to large blood vessels require application of the three-compartment tracer kinetic model calculations with no simplifying assumptions.
KeywordsStandard Uptake Value Cereb Blood Flow Large Blood Vessel Vascular Compartment Glucose Metabolic Rate
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- 1.Hawkins, R.A., Phelps, M.E., Huang, S.C. Effect of temporal sampling, glucose metabolic rates, and disruptions of the blood-brain barrier on the FDG. Model with and without a vascular compartment: studies in human brain tumors with PET. J. Cereb Blood Flow Metab 6, 170–1832.Google Scholar
- 2.Hoh, C.K., Dahlbom, M, Hawkins, R.A., et al (1994) Basic principles of positron emission tomography in oncology: quantification and whole body techniques. Wien Klin Wochenschr 106/15, 496–504Google Scholar
- 5.Evans, A.C., Diksic, M., Yamamoto, Y.L. et al (1986) Effect of vascular activity in the determination of rate constants for the uptake of F18-labeled 2-Fluoro-2-deoxy-D-glucose: error analysis and normal values in older subjects. (1986) J. Cereb Blood Flow Metab 6, 724–738PubMedCrossRefGoogle Scholar