The Development of Chromatographic 188W/188Re Generators for Therapy
The static and dynamic adsorption processes using alumina, oxides of zirconium(IV), yttrium (III), tin(IV) and solutions of tungsten (Cw=50–1000 μg/ml) have been investigated. The obtained values of capacity varied from 1,5 to 75 mg/g adsorbent. Several rhenium-188 generators based on alumina and zir-conium(IV) oxide were loaded with 370–1110 MBq high specific activity 188W. Carrier-free 188Re was eluted as sodium perrhenate with normal saline (3–17 ml) . Tested 188W/188Re generators showed high technical performance and reliability. The next step is the development of “full-scale” clinical generators and their testing using animals.
KeywordsDynamic Adsorption Sodium Tungstate Hydrous Zirconium Zirconium Hydroxide Daughter Radionuclide
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