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The Development of Chromatographic 188W/188Re Generators for Therapy

  • V. V. Basmanov
  • O. V. Kolesnik
  • N. P. Lisichkina
Conference paper
Part of the Advances in Pharmacological Sciences book series (APS)

Abstract

The static and dynamic adsorption processes using alumina, oxides of zirconium(IV), yttrium (III), tin(IV) and solutions of tungsten (Cw=50–1000 μg/ml) have been investigated. The obtained values of capacity varied from 1,5 to 75 mg/g adsorbent. Several rhenium-188 generators based on alumina and zir-conium(IV) oxide were loaded with 370–1110 MBq high specific activity 188W. Carrier-free 188Re was eluted as sodium perrhenate with normal saline (3–17 ml) . Tested 188W/188Re generators showed high technical performance and reliability. The next step is the development of “full-scale” clinical generators and their testing using animals.

Keywords

Dynamic Adsorption Sodium Tungstate Hydrous Zirconium Zirconium Hydroxide Daughter Radionuclide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • V. V. Basmanov
    • 1
  • O. V. Kolesnik
    • 1
  • N. P. Lisichkina
    • 1
  1. 1.Institute of Physics and Power EngineeringState Scientific Center of Russian FederationObninskRussia

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