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Rhenium-186-HEDP and Strontium-89-Chloride in Treatment of Metastatic Bone Pain

  • K. Liepe
  • W. G. Franke
  • R. Hliscs
  • A. Kühne
  • J. Kropp
Conference paper
Part of the Advances in Pharmacological Sciences book series (APS)

Abstract

In 25 patients we investigated the influence of Re-186 or Sr-89 on pain relief, reduction of analgesic consumption, and impairment of bone marrow function. We calculated the blood clearance, the excretion rate in urine and the accumulation in the bone. Blood samples were drawn weekly for 6 weeks and counted. 66% of the patients were able to reduce their analgesic intake. 66% of the patients had a significant, 17% a minor improvement of life quality. No differences were observed between the results of Sr-89 and Re-186-therapy. The excretion rate of Re-186 in the urine was 59% of the administered activity within 48h. Platelets decreased to 134.000 ± 68.000//mm3 and leucocytes to 4.300 ± 2.000/mm3. The bone accumulation of Re-186 was 36 ± 6%, with 17 ± 4% in the metastases as an average.

Keywords

Pain Relief Bone Metastasis Excretion Rate Blood Clearance Radionuclide Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • K. Liepe
    • 1
  • W. G. Franke
    • 1
  • R. Hliscs
    • 1
  • A. Kühne
    • 1
  • J. Kropp
    • 1
  1. 1.Department of Nuclear MedicineUniversity Hospital, Dresden University of TechnlogyDresdenGermany

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