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Garlic as an immunostimulant

  • Eikai Kyo
  • Naoto Uda
  • Shigeo Kasuga
  • Yoichi Itakura
  • Hiromichi Sumiyoshi
Part of the Progress in Inflammation Research book series (PIR)

Abstract

For over 5000 years, garlic has acquired a worldwide reputation in folklore as a formidable prophylactic and therapeutic medicinal agent [1–3]. More than three thousand publications in this century have confirmed the efficacy of this herb in the prevention and treatment of a variety of diseases, acknowledging and validating the traditional uses.

Keywords

Natural Killer Activity Garlic Extract Allium Sativum Aged Garlic Extract Garlic Powder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lau BHS, Adetumbi MA, Sanchez A (1983) Allium sativum (garlic) and atherosclerosis. Nutr Res 3: 119–128CrossRefGoogle Scholar
  2. 2.
    Adetumbi MA, Lau BHS (1983) Allium sativum (garlic) - a natural antibiotic. Med Hypotheses 12(3): 227–237PubMedCrossRefGoogle Scholar
  3. 3.
    Essman EJ (1984) The medicinal uses of herbs. Fitoterapia 55: 279–289Google Scholar
  4. 4.
    Fenwick GR, Hanley AB (1985) The genus Allium-Par 2. Crit Rec Food Sci 22: 273–377CrossRefGoogle Scholar
  5. 5.
    Ernst E (1987) Cardiovascular effects of garlic (Allium sativum): a review. Pharmather-apeutica 5: 83–89Google Scholar
  6. 6.
    Klendler BS (1987) Garlic (Allium sativum) and onion (Allium cepa): a review of their relationship to cardiovascular disease. Prevent Med 16: 670–685CrossRefGoogle Scholar
  7. 7.
    Kleijnen J, Knipschild P, ter Riet G (1989) Garlic, onion and cardiovascular risk factors. A review of the evidence from human experiments with emphasis on commercially available preparations. British J Clin Pharmacol 28: 535–544CrossRefGoogle Scholar
  8. 8.
    Warshafsky S, Kamer RS, Sivak SL (1993) Effect of garlic on total cholesterol, a meta-analysis. Ann Int Med 119: 599–605PubMedGoogle Scholar
  9. 9.
    Silagy CA, Neil HA (1994) A meta-analysis of the effect of garlic on blood pressure. J Hypertensions 12: 463–468Google Scholar
  10. 10.
    Sendl A (1995) Allium sativum and Allium ursinum: Part 1: Chemistry, analysis, history, botany. Phytomedicine 4: 323–339CrossRefGoogle Scholar
  11. 11.
    Reuter HD (1995) Allium sativum and allium ursinum: Part 2: Pharmacology and medicinal application. Phytomedicine 2: 73–91PubMedCrossRefGoogle Scholar
  12. 12.
    Sumiyoshi H, Wargovich MJ (1989) Garlic (Allium sativum): a review of its relationship to cancer. Asia Pacific J Pharmacol 4: 133–140Google Scholar
  13. 13.
    Dausch JG, Nixon DW (1990) Garlic: a review of its relationship to malignant disease. Preventive Medicine 19: 346–361PubMedCrossRefGoogle Scholar
  14. 14.
    Dorant E, van den Brandt PA, Goldbohm RA, Hermus RJ, Sturmans F (1993) Garlic and its significance for the prevention of cancer in human: a critical review. British J Cancer 67: 424–429CrossRefGoogle Scholar
  15. 15.
    Yang CS, Wang ZY, Hong JY (1994) Inhibition of tumorigenesis by chemicals from garlic and teas. In: Jacobs MM (ed): Diet and cancer: Markers, prevention, and treatment. Plenum Press, New York, 113–122Google Scholar
  16. 16.
    Ip C, Lisk DJ, Scimeca JA (1994) Potential of food modification in cancer prevention. Cancer Res 54: 1957s-1959sPubMedGoogle Scholar
  17. 17.
    Caragay AB (1992) Cancer-preventive foods and ingredients. Food Technol 4: 65–68Google Scholar
  18. 18.
    Weisberger AS, Pensky J (1957) Tumor-inhibiting effects derived from an active principle of garlic (Allium sativum). Science 126: 1112–1114PubMedCrossRefGoogle Scholar
  19. 19.
    Brosche T, Platt D (1993) Zur immunomodulatorische Wirkung von Knoblauch (Allium sativum L.). Med Welt 44: 309–313Google Scholar
  20. 20.
    Hirao Y, Sumioka I, Nakagami S, Yamamoto M, Hatono S, Fuwa T, Nakagawa S (1987) Activation of immunoresponder cells by the protein fraction from aged garlic extract. Phytother Res 1: 161–164CrossRefGoogle Scholar
  21. 21.
    Lau BHS (1989) Detoxifying, radio-protective and phagocyte-enhancing effects of garlic. Int Clin Nutr Rev 9: 27–31Google Scholar
  22. 22.
    Lau BHS, Lau MD, Yamasaki T, Gridley DS (1991) Garlic compounds modulate macrophage and T-lymphocyte functions. Mol Biother 3: 103–7PubMedCrossRefGoogle Scholar
  23. 23.
    Morioka N, Sze LL, Morton DL, Irie RF (1993) A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunol Immunother 37: 316–322PubMedCrossRefGoogle Scholar
  24. 24.
    Kyo E, Uda N, Suzuki A, Kakimoto M, Ushijima M, Kasuga S, Itakura Y (1997) Immuno-modulation and anti-tumor activities of Aged Garlic Extract. Phytomedicine 5 (4): 259–267CrossRefGoogle Scholar
  25. 25.
    Burger RA, Warren RP, Lawson LD, Hughes BG (1993) Enhancement of in vitro human immune function by Allium sativum L. (garlic) fraction. Int J Pharmacogn 31: 169–174CrossRefGoogle Scholar
  26. 26.
    Gupta JB, Godhwani JL (1984) Modification of immunological response by garlic, guggal, and tumeric in albino rats. Indian J Pharmacol 16: 62–63Google Scholar
  27. 27.
    Arzamastsev EV (1993) Immunomodulating properties of garlic powder. Unpublished data presented at the International Conference “New Mechanism for Preventive and Therapeutic Actions of Garlic”, Nuremberg, 11–22 JanuaryGoogle Scholar
  28. 28.
    Zhang YX, Saito H, Nishiyama N (1994) Ameliorating effect of aged garlic extract (AGE) on learning behaviours in thymectomixed senescence accelerated mouse (SAM). In: Take-da T (ed): The SAM model of senescence. Excerpta Medica, Amsterdam 451–454Google Scholar
  29. 29.
    Lau BHS, Woolley JL, Marsh CL, Barker GR, Koobs DH, Torrey RR (1986) Superiority of intralesional immunotherapy with corynebacterium parvum and allium sativum in control of murine transitional cell carcinoma. J Urol 136: 701–705PubMedGoogle Scholar
  30. 30.
    Marsh CL, Torrey RR, Woolley JL, Barker GR, Lau BHS (1987) Superiority of intralesional immumotherapy with corynebacterium parvum and allium sativum in control of murine bladder cancer. J Urol 137: 359–362PubMedGoogle Scholar
  31. 31.
    Riggs DR, DeHaven JI, Lamm DL (1997) Allium sativum (garlic) treatment for murine transitional cell carcinoma. Cancer 79: 1987–94PubMedCrossRefGoogle Scholar
  32. 32.
    Yokoyama K, Uda N, Takasugi N, Fuwa T (1986) Anti-stress effects of garlic extract preparation containing vitamins (Kyoleopin) and ginseng-garlic preparation containing vitamin bl (Leopin-five) in mice. Oyo Yakuri (Appl Pharma) 31: 977–984Google Scholar
  33. 33.
    Lembo G, Balato N, Patruno C et al (1991) Allergic contact dermatitis due to garlic (Allium sativum). Contact Dermatitis 25: 330–331PubMedCrossRefGoogle Scholar
  34. 34.
    McFadden JP, White IR, Rycroft RJG (1992) Allergic contact dermatitis from garlic. Contact Dermatitis 27: 333–334PubMedCrossRefGoogle Scholar
  35. 35.
    Lybarger JA, Gallagher JS, Pulver DW et al (1982) Occupational asthma induced by inhalation and ingestion of garlic. J Allergy Clin Immunol 69: 448–454PubMedCrossRefGoogle Scholar
  36. 36.
    Tanaka Y, Kataoka M, Konishi Y, Nishimune T, Takagaki, Y (1992) Effects of vegetable foods on b-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3). Jpn J Toxicol Environ Health 38: 418–24CrossRefGoogle Scholar
  37. 37.
    Kyo E, Uda N, Kakimoto M, Yokoyama K, Ushijima M, Sumioka I, Kasuga S, Itakura Y (1997) Anti-allergic effects of Aged Garlic Extract. Phytomedicine 4 (4): 335–340PubMedCrossRefGoogle Scholar
  38. 38.
    Shah SA, Vohora SB (1990) Boron enhances antiarthritic effects of garlic oil. Fitoterapia 61: 121–126Google Scholar
  39. 39.
    Nagai K (1973) Experimental studies on the preventative effect of garlic extract against infection with influenza virus. Kansenshogaku-zassi (Jpn J Infect Disease) 47(9): 321– 325Google Scholar
  40. 40.
    Tadi PP, Teel RW, Lau BHS (1990) Anticandidal and anticarcinogenic potentials of garlic. Int Clin Nutr Rev 10: 423–429Google Scholar
  41. 41.
    Reeve VE, Bosnic M, Rozinova E, Boehm-Wilcox C (1983) A garlic extract protects from ultraviolet B (280–320 nm) radiation-induced suppression of contact hypersensitivity. Photochem Photobiol 58(6): 813–817CrossRefGoogle Scholar
  42. 42.
    Brosche T, Platt D (1994) Knoblauchtherapie and zelluläre Immunabwehr im Alter. Z Phytother 15: 23–24Google Scholar
  43. 43.
    Kandil O, Abdullah TH, Elkadi A (1987) Garlic and the immune system in humans: its effect on natural killer cells. Fed Proc 46: 441Google Scholar
  44. 44.
    Kandil O, Abdullah TH, Tabuni AM, Elkadi A (1988) Potential role of Allium sativum in natural cytotoxicity. Arch AIDS Res 1: 230–231Google Scholar
  45. 45.
    Abdullah TH, Kirkpatrick DV, Carter J (1989) Enhancement of natural killer cell activity in AIDS with garlic. J Oncol 21: 52–53Google Scholar
  46. 46.
    Feng ZH, Zhang GM, Hao TL, Zhou B, Zhang H, Jiang ZY (1994) Effect of diallyl trisulfide on the activation of T-cell and macrophage-mediated cytotoxicity. J Tongji Med Univ 14: 142–147PubMedCrossRefGoogle Scholar
  47. 47.
    Smeets K, Van Damme EJ, Verhaert P, Barre A, Rouge P, Van Leuven F, Peumans WJ (1997) Isolation, characterization and molecular cloning of the mannose-binding lectins from leaves and roots of garlic (Allium sativum L.). Plant Mol Biol 33(2): 223–234PubMedCrossRefGoogle Scholar
  48. 48.
    Gupta A, Sandhu RS (1997) A new high molecular weight agglutinin from garlic (Alli-um sativum). Mol and Cell Biochem 166(1–2): 1–9CrossRefGoogle Scholar
  49. 49.
    Mosmonn T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63CrossRefGoogle Scholar
  50. 50.
    Ishiyama M, Shiga M, Sasamoto K, Mizoguchi M, He PG (1993) A new sulfonated tetrazolium salt that produces a highly water-soluble formazan dye. Chem Pharm Bull 41: 1118–1122CrossRefGoogle Scholar
  51. 51.
    Stewart CC, Lehnert BE, Steinkamp JA (1986) in vitro and in vivo measurement of phagocytosis by flow cytometry. Methods in Enzym 132: 183–192CrossRefGoogle Scholar
  52. 52.
    Rosenstreich DL, Blake JT, Rosenthal AS (1971) The peritoneal exudate lymphocytes. I. Differences in antigen responsiveness between peritoneal exudate and lymph node lymphocytes from immunized guinea pigs. J Exp Med 134: 1170–1186PubMedCrossRefGoogle Scholar

Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Eikai Kyo
    • 1
  • Naoto Uda
    • 1
  • Shigeo Kasuga
    • 1
  • Yoichi Itakura
    • 1
  • Hiromichi Sumiyoshi
    • 2
  1. 1.Pharmacology and Safety Assessment Laboratory of Institute for OTC ResearchJapan
  2. 2.OTC Development DepartmentWakunaga Pharmaceutical Co., Ltd.HiroshimaJapan

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