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Neuropeptides and the gut: Tachykinins and calcitonin gene-related peptide in intestinal inflammation and pain

  • Chapter
Pain and Neurogenic Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Intestinal functions are under the control of extrinsic afferent neurons, extrinsic efferent neurons of the sympathetic and parasympathetic autonomic nervous system and the intrinsic neurons of the enteric nervous system. Apart from the classical transmitters acetylcholine and noradrenaline, these neurons express a variety of neuropeptides including the tachykinins substance P (SP) and neurokinin A (NKA), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP) and neuropeptide Y [1]. Nerve activity leads to exocytotic release of the peptides which, by interacting with specific receptors on postjunctional neurons or effector cells, participate in the regulation of gastrointestinal motility, secretion, circulation and tissue homeostasis. After recognition of the physiological roles of peptidergic neurons and neuropeptides in the gut it is becoming increasingly evident that gastrointestinal inflammation and other disorders may be related to imbalanced function of certain neuropeptide systems. The conjecture that neuropeptides have a bearing on gastrointestinal disease has been most advanced for SP, NKA and CGRP, and it is with these peptides that the present article is concerned.

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  1. Department of Experimental and Clinical Pharmacology, University of Graz, Universitätsplatz 4, Graz, A-8010, Austria

    Peter Holzer

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  1. Cardiovascular Research Centre, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Susan D. Brain

  2. Messengers and Signalling Group, Division of Biomedical Sciences, King’s College London, Manresa Road, SW3 6LX, London, UK

    Philip K. Moore

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Holzer, P. (1999). Neuropeptides and the gut: Tachykinins and calcitonin gene-related peptide in intestinal inflammation and pain. In: Brain, S.D., Moore, P.K. (eds) Pain and Neurogenic Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8753-3_12

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  • DOI: https://doi.org/10.1007/978-3-0348-8753-3_12

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9758-7

  • Online ISBN: 978-3-0348-8753-3

  • eBook Packages: Springer Book Archive

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