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Mast Cell Proteases as New Targets for Therapeutic Intervention in Asthma

  • Steven J. Compton
  • Andrew F. Walls
Chapter
Part of the Progress in Inflammation Research book series (PIR)

Abstract

Mast cells have long attracted attention for their potential to contribute to the disease process in asthma [1]. These cells are widely distributed throughout the body, but are particularly prevalent in tissues which form an interface with the external environment. In the lower airways mast cells are numerous in the bronchial mucosa [2], submucosa and alveolar walls [3], and are even found free in the lumen [4]. The activation of mast cells by allergen or by other stimuli is associated with the rapid release of a range of potent mediators of inflammation and bronchoconstriction.

Keywords

Mast Cell Allergy Clin Immunol Mast Cell Activation Human Mast Cell Mast Cell Tryptase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Steven J. Compton
    • 1
  • Andrew F. Walls
    • 1
  1. 1.Immunopharmacology GroupUniversity of Southampton, Southampton General HospitalSouthamptonUK

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