Mast Cell Stabilizing Drugs

  • Guy F. Joos
  • Renaat A. Peleman
  • Romain A. Pauwels
Part of the Progress in Inflammation Research book series (PIR)


Currently available medication for treating airway inflammation is limited to only a few proven antiinflammatory agents. Cromolyn sodium (sodium cromoglycate, SCG) and nedocromil sodium, traditionally referred to as mast cell stabilizing agents, comprise an important group of mild to moderate anti-inflammatory drugs [1].


Mast Cell Sodium Cromoglycate Airway Responsiveness Human Bronchial Epithelial Cell Beclomethasone Dipropionate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    National Institutes of Health (1997) NIH publication nr. 97-4051A.: Guidelines for the diagnosis and management of asthma. May, 21Google Scholar
  2. 2.
    Altounyan REC (1967) Inhibition of experimental asthma by a new compound, disodium cromoglycate. Acta Allergol 22: 487–492Google Scholar
  3. 3.
    Cox JCG (1967) Cromoglycate (FPL 670)(‘Intal): a specific inhibitor of reaginic antibody-antigen mechanisms. Nature 216: 1328–1329PubMedCrossRefGoogle Scholar
  4. 4.
    Church MK, Young KD (1983) The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine Br J Pharmacol 78: 671–679PubMedCrossRefGoogle Scholar
  5. 5.
    Church MK, Hiroi J (1987) Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Br J Pharmacol 90: 421–429PubMedCrossRefGoogle Scholar
  6. 6.
    Flint KC, Leung KBP, Pearce FL, Hudspith BN, Brostoff J, McJohnson I (1985) Human mast cells recovered by bronchoalveolar lavage: their morphology, histamine release and the effects of sodium cromoglycate. Clin Science 68: 427–432Google Scholar
  7. 7.
    Orr TSC (1973) Mast cells and allergic asthma. Br J Dis Chest 67: 87–106PubMedCrossRefGoogle Scholar
  8. 8.
    Kay AB (1987) The mode of action of anti-allergic drugs. Clin Allergy 17: 153–164PubMedCrossRefGoogle Scholar
  9. 9.
    Kimata H, Fujimoto M, Mikawa H (1994) Nedocromil sodium acts directly on human B cells to inhibit immunoglobulin production without affecting cell growth. Immunology 81: 47–52PubMedGoogle Scholar
  10. 10.
    Dixon CM, Jackson DM, Richards IM (1979) The effects of sodium cromoglycate on lung irritant receptors and left ventricular cardiac receptors in the anaesthetized dog. Br J Pharmacol 67: 569–574PubMedCrossRefGoogle Scholar
  11. 11.
    Biggs DF, Goel N (1985) Mechanisms of action of sodium cromoglycate. Can J Physiol Pharmacol 63: 760–765PubMedCrossRefGoogle Scholar
  12. 12.
    Booij-Noord H, Orie NGM, de Vries K (1971) Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy 48: 344–354Google Scholar
  13. 13.
    Cockcroft DW, Murdock KY (1987) Comparative effects of inhaled salbutamol, sodium cromoglycate and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses, and increased bronchial responsiveness to histamine. J Allergy Clin Immunol 79: 734–740PubMedCrossRefGoogle Scholar
  14. 14.
    Pauwels RA, Joos GF, Van Der Straeten ME (1988) Bronchial hyperresponsiveness is not bronchial asthma. Clin Allergy 18: 317–332PubMedCrossRefGoogle Scholar
  15. 15.
    Silverman M, Andrea T (1972) Time course of effect of disodium cromoglycate on exercise-induced asthma. Arch Dis Child 47: 419–422PubMedCrossRefGoogle Scholar
  16. 16.
    Deal EC, Wasserman SI, Soter NA, Ingram RH, McFadden ER (1980) Evaluation of role played by mediators of immediate hypersensitivity in exercise-induced asthma. J Clin Invest 65: 659–665PubMedCrossRefGoogle Scholar
  17. 17.
    Breslin FJ, McFadden ER Jr, Ingram RH Jr (1980) The effect of cromolyn sodium on the airway response to hyperpnea and cold air in asthma. Am Rev Respir Dis 122: 11–16PubMedGoogle Scholar
  18. 18.
    Holgate ST (1989) Reflections on the mechanisms of action of sodium cromoglycate (Intal) and the role of mast cells in asthma. Respir Med 83: 25–31PubMedCrossRefGoogle Scholar
  19. 19.
    Dixon CM, Barnes PJ (1989) Bradykinin-induced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate. Br J Clin Pharmacol 27: 831–836PubMedCrossRefGoogle Scholar
  20. 20.
    Dixon CM, Fuller RW, Barnes PJ (1987) Effect of nedocromil sodium on sulphur dioxide induced bronchoconstriction. Thorax 42: 462–465PubMedCrossRefGoogle Scholar
  21. 21.
    Dixon CM, Ind PW (1988) Metabisulfite induced bronchoconstrictiommechanisms. Am Rev Respir Dis 137: 238Google Scholar
  22. 22.
    Löwhagen O, Rak S (1985) Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season. J Allergy Clin Immunol 75: 460–467PubMedCrossRefGoogle Scholar
  23. 23.
    Löwhagen O, Rak S (1985) Bronchial hyperreactivity after treatment with sodium cromoglycate in atopic asthmatics not exposed to relevant allergens. J Allergy Clin Immunol 75: 343–347PubMedCrossRefGoogle Scholar
  24. 24.
    Petty TL, Rollins DR, Christopher K, Good JT, Oakley R (1989) Cromolyn sodium is effective in adult chronic asthmatics. Am Rev Respir Dis 139: 694–701PubMedGoogle Scholar
  25. 25.
    Edwards AM (1994) Sodium cromoglycate (Intal) as an anti-inflammatory agent for the treatment of chronic asthma. Clin Exper Allergy 24: 612–623CrossRefGoogle Scholar
  26. 26.
    Tasche MJA, 5van der Wouden JC, Uijen JHJM, Ponsioen BP, Bernsen RMD, van Suijlekom-Smit LWA, de Jongste JC (1997) Randomised placebo-controlled trial of inhaled sodium cromoglycate in 1–4-year old children with moderate asthma. Lancet 350: 1060–1064PubMedCrossRefGoogle Scholar
  27. 27.
    Hargreaves MR, Benson MK (1995) Inhaled sodium cromoglycate in angiotensin-converting enzyme inhibitor cough. Lancet 345: 13–16PubMedCrossRefGoogle Scholar
  28. 28.
    Morrison-Smith J (1979) Prolonged use of disodium cromoglycate in children and young persons — ten years experience. In: J Pepys, AM Edwards (eds): The mast cell — Its role in health and disease. Pitman Medical, Davos, London, 280–282Google Scholar
  29. 29.
    de Jong JW, Postma DS, de Monchy JGR, Koeter GH (1993) A review of nedocromil sodium in asthma therapy. Eur Respir J 3: 511–519Google Scholar
  30. 30.
    Borish L, Williams J, Johnson S, Mascali JJ, Miller R et al (1992) Anti-inflammatory effects of nedocromil sodium: inhibition of alveolar macrophage function. Clin Exper Allergy 62: 38–41Google Scholar
  31. 31.
    Vittori E, Sciacca F, Colotta F, Mantovani A, Mattoli S (1992) Protective effect of nedocromil sodium on the interleukin-1-induced production of interleukin-8 in human bronchial epithelial cells. J Allergy Clin Immunol 90: 76–84PubMedCrossRefGoogle Scholar
  32. 32.
    Devalia JL, Rusznak C, Calderon, Sapsford RJ, Davis R (1994) The effect of nedocromil sodium on ozone-induced synthesis of cytokines by human bronchial epithelial cell cultures in vitro. Am J Respir Crit Care Med 149: A317Google Scholar
  33. 33.
    Marini M, Soloperto M, Zheng Y, Mezzetti M, Mattoli S (1992) Protective effect of nedocromil sodium on the IL-1-induced release of GM-CSF from cultured human bronchial epithelial cells. Pulmonary Pharmacology 5: 61–65PubMedCrossRefGoogle Scholar
  34. 34.
    Schoonbrood DFM, Out TA, Hart AAM, Habets FJM, Roos CM, Jansen H (1997) Nedocromil sodium in obstructive airways disease: effect on symptoms and plasma protein leakage in sputum. Eur Respir J 10: 1500–1506PubMedCrossRefGoogle Scholar
  35. 35.
    Gilbert IA, Logan LS, Hassan MO, Abdul-Karim F, Kenner KA, Nelson JA, McFadden ER (1994) Influence of nedocromil sodium on airway inflammation in asthmatics. Am J Respir Crit Care Med 149: A941Google Scholar
  36. 36.
    Manolitsas ND, Wang J, Devalia JL et al (1995) Regular albuterol, nedocromil sodium and bronchial inflammation in asthma. Am J Respir Crit Care Med 151: 1925–1930PubMedGoogle Scholar
  37. 37.
    Leung KBP, Flint KC, Brostoff J (1988) Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax 43: 756–761PubMedCrossRefGoogle Scholar
  38. 38.
    Maxwell DL, Hawksworth RJ, Lee TH (1993) Inhaled nedocromil sodium reduces histamine release from isolated large airway segments of asthmatic subjects in vivo. Eur Respir J 6: 1145–1150PubMedGoogle Scholar
  39. 39.
    Verleden GM, Belvisi MG, Stretton CD, Barnes PJ (1991) Nedocromil sodium modulates nonadrenergic, noncholinergic bronchoconstrictor nerves in guinea pig airways in vitro. Am Rev Respir Dis 143: 114–118PubMedGoogle Scholar
  40. 40.
    Dahl R, Pedersen B (1986) Influence of nedocromil sodium on the dual asthmatic reactions after allergen challenge: a double blind, placebo-controlled study. Eur J Respir Dis 69 (suppl 147): 263–265Google Scholar
  41. 41.
    Aalbers R, Kauffman HF, Groen H, Koeter GH, de Monchy JGR (1991) The effect of nedocromil sodium on the early and late reaction and allergen-induced bronchial hyper-responsiveness. J Allergy Clin Immunol 87: 993–1001PubMedCrossRefGoogle Scholar
  42. 42.
    Crimi N, Violante B, Pellegrino R, Brusasco V (1993) Effect of multiple doses of nedrocromil sodium given after inhalation in asthma. J Allergy Clin Immunol 92: 777–783PubMedCrossRefGoogle Scholar
  43. 43.
    Crimi N, Palermo F, Oliveri R, Vancheri C, Polosa R, Palermo B, Maccarrone C, Mistretta A (1988) Comparative study of the effects of nedocromil sodium (4 mg) and sodium cromoglycate (10 mg) on adenosine-induced bronchoconstriction in asthmatic subjects. Clin Allergy 18: 367–374PubMedCrossRefGoogle Scholar
  44. 44.
    Altounyan REC, Lee TB, Rocchicciolo KMS, Shaw CL (1986) A comparison of the inhibitory effects of nedocromil sodium and sodium cromoglycate on adenosine mono-phosphate-induced bronchoconstriction in atopic subjects. Eur J Respir Dis 69 (suppl 147): 277–279Google Scholar
  45. 45.
    Joos GF, Pauwels RA, Van Der Straeten ME (1989) The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. J Allergy Clin Immunol 83: 663–668PubMedCrossRefGoogle Scholar
  46. 46.
    Crimi N, Palermo F, Oliveri R, Palermo B, Vancheri C, Polosa R, Mestretta A (1988) Effect of nedocromil on bronchospasm induced by inhalation of substance P in asthmatic subjects. Clin Allergy 18: 375–382PubMedCrossRefGoogle Scholar
  47. 47.
    Wright W, Zhang YFG, Salme, CM, Woolcock AJ (1990) Effect of inhaled preservatives on asthmatic subjects. I. Sodium metabisulfite. Am Rev Respir Dis 141: 1400–1404PubMedGoogle Scholar
  48. 48.
    Robuschi M, Vaghi A, Simone P, Bianco S (1987) Prevention of fog-induced bronchospasm by nedocromil sodium. Clin Allergy 17: 69–74PubMedCrossRefGoogle Scholar
  49. 49.
    Roberts JA, Thomson NC (1985) Attenuation of exercise-induced asthma by pretreatment with nedocromil sodium and minocromil. Clin Allergy 15: 377–381PubMedCrossRefGoogle Scholar
  50. 50.
    Juniper EF, Kline PA, Morris MM, Hargreave FE (1987) Airway constriction by isocapnic hyperventilation of cold, dry air: comparison of magnitude and duration of protection by nedocromil sodium and sodium cromoglycate. Clin Allergy 17: 523–528PubMedCrossRefGoogle Scholar
  51. 51.
    Dorward AJ, Roberts JA, Thomson NC (1986) Effect of nedocromil sodium on histamine airway responsiveness in grass-pollen sensitive asthmatics during the pollen season. Clin Allergy 16: 309–315PubMedCrossRefGoogle Scholar
  52. 52.
    Orefice U, Struzzo PL, Pitzalis G, Dei D (1989) A double-blind multicenter group comparative study of the efficacy and safety of nedocromil sodium in the management of asthma. Chest 97: 1299–1306Google Scholar
  53. 53.
    Bel EH, Timmers MC, Hermans J, Dijkman JH, Sterk PJ (1990) The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects. Am Rev Respir Dis 141: 21–28PubMedGoogle Scholar
  54. 54.
    Groot CAR, Lammers JWJ, Molema J, Festen J, Van Herwaarden CLA (1992) Effects of inhaled beclomethasone and nedocromil sodium on bronchial hyperresponsiveness to histamine and distilled water. Eur Respir J 5: 1075–1082PubMedGoogle Scholar
  55. 55.
    Marcoux JP, Findlay SR, Furukaway CT (1992) A placebo-controlled comparison of nedocromil sodium (Tilade) and salbutamol in mild to moderate asthma. Eur Respir J 5:83s (abstract)Google Scholar
  56. 56.
    de Jong JW, Teengs JP, Postma DS, van der Mark TW, Koeter GH, de Monchy JGR (1994) Nedocromil sodium versus albuterol in the management of allergic asthma. Am J Respir Crit Care Med 149: 91–97PubMedGoogle Scholar
  57. 57.
    Wasserman SI, Furukawa CT, Henochowicz SI et al (1995) Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol. J Allergy Clin Immunol 95: 541–547PubMedCrossRefGoogle Scholar
  58. 58.
    Jones PW (1994) Nedocromil sodium quality of life study group. Quality of life, symptoms and pulmonary function in asthma: long-term treatment with nedocromil sodium examined in a controlled multicentre trial. Eur Respir J 7: 55–62PubMedCrossRefGoogle Scholar
  59. 59.
    Fink J, Forman S, Silvers SS, Soifer MM, Tashkin DP, Wilson AF (1994) A double-blind study of the efficacy of nedocromil sodium in the management of asthma in patients using high doses of bronchodilators. J Allergy Clin Immunol 94: 473–481PubMedCrossRefGoogle Scholar
  60. 60.
    Goldin JG, Bateman ED (1988) Does nedocromil sodium have a steroid sparing effect in adult asthmatic patients requiring maintenance oral corticosteroids? Thorax 43: 982–9866.PubMedCrossRefGoogle Scholar
  61. 61.
    Boulet LP, Carder A, Cockcroft DW et al (1990) Tolerance to reduction of oral steroid dosage in severely asthmatic patients receiving nedocromil sodium. Respir Med 84: 317–323PubMedCrossRefGoogle Scholar
  62. 62.
    Orefice U, Struzzo P, Dorigo R, Peratoner A (1990) Long-term effects of nedocromil sodium and beclomethasone diproprionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects. Am Rev Respir Dis 141: 21–28Google Scholar
  63. 63.
    Marin JS, Carrizo SJ, Garcia R, Ejea MV (1996) Effects of nedocromil sodium in steroidresistant asthma: a randomized controlled trial. J Allergy Clin Immunol 97: 602–610PubMedCrossRefGoogle Scholar
  64. 64.
    de Jong JW, Postma DS, van der Mark TW, Koeter GH (1994) Effects of nedocromil sodium in the treatment of non-allergic subjects with chronic obstructive pulmonary disease. Thorax 49: 1022–1024PubMedCrossRefGoogle Scholar

Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Guy F. Joos
    • 1
  • Renaat A. Peleman
    • 1
  • Romain A. Pauwels
    • 1
  1. 1.Department of Respiratory DiseasesUniversity Hospital GhentGhentBelgium

Personalised recommendations