Cytokine and Adhesion Molecule Antagonists

  • Paul S. Foster
  • Simon P. Hogan
Part of the Progress in Inflammation Research book series (PIR)


The proposed central role of specific leukocyte subsets in the pathophysiology of asthma has focused attention on the development of agents that will selectively inhibit the migration of these inflammatory cells into the lung. In asthma, airway CD4+ Th2 type lymphocytes, mast cells and eosinophils appear to be primarily effector cells that underlie the clinical manifestations of disease [1]. The cellular and molecular mechanisms involved in the regulation of the recruitment of these inflammatory cells from the blood to sites of inflammation are complex, however, cellular migration appears to be modulated by two fundamental processes; cell-adhesion systems located in the vascular endothelium and signals elicited through cytokine and chemokine (chemoattractant cytokines) receptors. Cell-adhesion and cytokine signalling systems form networks that are elegantly coordinated to promote cellular extravasation and localisation to the site of inflammation [2, 3]. At the initiation of inflammation, cytokines and chemokines play key roles in propagating the inflammatory response by eliciting signals that activate adhesion-systems, induce the secretion of other cytokines/chemokines from the vascular bed and promote chemotaxis. The type of cytokines produced in response to a particular inflammatory stimulus are intimately involved in directing the immune response by promoting the selective mobilization, attachment and recruitment of specific leukocyte sub-sets to the site of provocation [2–4].


Respir Crit Adhesion System Airway Hyperresponsiveness Allergic Inflammation Allergic Airway Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Basel AG 1999

Authors and Affiliations

  • Paul S. Foster
    • 1
  • Simon P. Hogan
    • 1
  1. 1.Division of Biochemistry and Molecular Biology, John Curtin School of Medical ResearchAustralian National UniversityActon ACTAustralia

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