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Inducible enzymes In the pathogenesis of rheumatoid arthritis

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Inducible Enzymes in the Inflammatory Response

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Rheumatoid arthritis (RA) is a progressive debilitating inflammatory disease of unknown aetiology. The incidence of arthritis within the community is approximately 2–3% and, on average, accounts for the loss of 88 million working days per year. Thus, chronic inflammatory diseases like RA impose a considerable financial burden on national economies. Intervention therapy tends merely to limit inflammation and may induce adverse reactions but, in general, there is little effect on disease progression, possibly highlighting our misconception of the disease process. To this end, novel therapeutic targets are essential.

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Authors and Affiliations

  1. Bone and Joint Medicine, Department of Postgraduate Medicine, University of Bath, Claver-ton Down, Bath BA2 7AY, UK

    Vivienne R. Winrow & David R. Blake

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  1. Vivienne R. Winrow
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  2. David R. Blake
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  1. Department of Experimental Pathology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Derek A. Willoughby  & Annette Tomlinson  & 

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Winrow, V.R., Blake, D.R. (1999). Inducible enzymes In the pathogenesis of rheumatoid arthritis. In: Willoughby, D.A., Tomlinson, A. (eds) Inducible Enzymes in the Inflammatory Response. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8747-2_4

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  • DOI: https://doi.org/10.1007/978-3-0348-8747-2_4

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9755-6

  • Online ISBN: 978-3-0348-8747-2

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