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Inducible nitric oxide synthase and inflammation

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Inducible Enzymes in the Inflammatory Response

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Introduction During both acute and chronic inflammatory processes profound physiological adaptations are triggered in an attempt to limit tissue damage and remove the pathogenic insult. Such mechanisms include local and systemic vasodilatation, pyresis and the activation of the immune system. These changes are regulated by a number of diverse mediators such as cytokines, bacterial products, (neuro)peptides and eicosanoids. Moreover, the considerable advances in the understanding of the role of nitric oxide (NO) as an inter- and intra- cellular messenger molecule have also established that NO plays an important role as a mediator of inflammation.

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Authors and Affiliations

  1. Wolfson Institute for Biomedical Research, Rayne Institute, University College London, 5 University Street, London, WC1E 6JJ, UK

    Adrian J. Hobbs & Salvador Moncada

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  1. Adrian J. Hobbs
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  2. Salvador Moncada
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  1. Department of Experimental Pathology, St. Bartholomew’s and The Royal London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK

    Derek A. Willoughby  & Annette Tomlinson  & 

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© 1999 Springer Basel AG

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Hobbs, A.J., Moncada, S. (1999). Inducible nitric oxide synthase and inflammation. In: Willoughby, D.A., Tomlinson, A. (eds) Inducible Enzymes in the Inflammatory Response. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8747-2_2

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  • DOI: https://doi.org/10.1007/978-3-0348-8747-2_2

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9755-6

  • Online ISBN: 978-3-0348-8747-2

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