Abstract
The process of leukocyte emigration into a site of inflammation involves a number of sequential and coordinated adhesive interactions between the leukocyte and underlying endothelium. As has been made clear in previous chapters, emigration can be dissected into the steps of tethering, rolling, activation, firm adhesion, and transendothelial migration. These interactions typically involve distinct families of cell adhesion molecules (CAMs). It is our ability to block the actions of these molecules by specific monoclonal antibodies (mAb), soluble recombinant CAMs or their ligands, or genetic disruption that has identified these as distinct steps [1,2].
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Muller, W.A. (1999). The role of PECAM in leukocyte emigration. In: Pearson, J.D. (eds) Vascular Adhesion Molecules and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8743-4_7
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DOI: https://doi.org/10.1007/978-3-0348-8743-4_7
Publisher Name: Birkhäuser, Basel
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