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SmithKline Beecham Pharmaceuticals’ cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SK&F 104353) and SK&F 106203

  • Chapter
Novel Inhibitors of Leukotrienes

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

SmithKline Beecham’s (SB) entrance into the cysteinyl leukotriene (Cys-LT) research arena began around 1976 with the creation of an “SRS-A” antagonist feasibility study at Smith Kline & French Laboratories. Following the information in the literature in 1979 and 1980 that the Cys-LTs were responsible for the physicochemical and biological properties of the “slow reacting substance of anaphylaxis” (SRS-A), increased attention and resources were focused on Cys-LT research, which was directed towards identifying novel therapeutics which will inhibit the synthesis of the Cys-LTs (5-lipoxygenase (5-LO) inhibitors) or block the effects of the Cys-LTs (receptor antagonists). In this chapter only the latter strategy will be reviewed. In addition to the internal SB discovery activities to identify Cys-LT receptor antagonists for potential clinical development, a compound, pranlukast (Ono-1078; SB 205312; Onon), was in-licensed from Ono Pharmaceuticals. The pharmacological properties of pranlukast, and the key compounds from SB’s own medicinal chemistry efforts, namely pobilukast (SK&F 104353) and SK&F 106203, will be presented.

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Authors and Affiliations

  1. Department of Pulmonary Pharmacology, UW2532, SmithKline Beecham Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA, 19406, USA

    Douglas W. P. Hay

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  1. Douglas W. P. Hay
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Editors and Affiliations

  1. Center for Cardiopulmonary Pharmacology Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan, 20133, Italy

    Giancarlo Folco

  2. Department of Medical Biochemistry and Biophysics Division of Physiological Chemistry II, Karolinska Institute, Stockholm, 10401, Sweden

    Bengt Samuelsson

  3. National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO, 80206, USA

    Robert C. Murphy

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© 1999 Springer Basel AG

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Hay, D.W.P. (1999). SmithKline Beecham Pharmaceuticals’ cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SK&F 104353) and SK&F 106203. In: Folco, G., Samuelsson, B., Murphy, R.C. (eds) Novel Inhibitors of Leukotrienes. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8703-8_20

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  • DOI: https://doi.org/10.1007/978-3-0348-8703-8_20

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9736-5

  • Online ISBN: 978-3-0348-8703-8

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