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The forensic significance of various reference population databases for estimating the rarity of variable number of tandem repeat (VNTR) loci profiles

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DNA Fingerprinting: State of the Science

Part of the book series: Progress in Systems and Control Theory ((EXS))

Summary

The likelihood of occurence of 1,964-HaeIII-generated target DNA profiles was estimated using fixed bin VNTR frequencies from various Caucasian, Black, and Hispanic databases and the product rule. The data in this study demonstrate that for forensic purposes there are smaller differences in statistical estimates of DNA profile frequencies among subgroup databases than among estimates across major population databases. This observation does not support the premise asserted by the NCR Report (1992) that the differences among subgroups within a race would be greater than between races (at least for forensic purposes). Therefore, the data do not support the need for alternative procedures, such as the ceiling principle approach (NRC Reports, 1992), for deriving statistical estimates of DNA profile frequencies. Comparisons across major population groups provide reasonable, reliable, and meaningful estimates of DNA profile frequencies without forensically significant consequences.

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References

  • Balazs I, Baird M, Clyne M, Meade E (1992) Human population genetic studies of five hypervariable DNA loci. American Journal of Human Genetics 44: 182–190

    Google Scholar 

  • Brookfield J (1992) Brookfield replies. Nature 358: 483

    Article  Google Scholar 

  • Budowle B, Giusti AM, Waye JS, Baechtel FS, Fourney RM, Adams DE, Presley LA, Deadman HA, Monson KL (1991) Fixed-Bin analysis for statistical evaluation of continuous distributions of allelic data from VNTR loci, for use in forensic comparisons. Am J Hum Genet 48: 841–855

    Google Scholar 

  • Cerda-Flores RM, Kshatriya GK, Barton SA, Leal-Garza CH, Garza-Chapa R, Schull WJ, Chakraborty, R (1991) Genetic structure of the populations migrating from San Luis Potosi and Zacatecas to Nuevo Leon in Mexico. Human Biology 63: 309–327

    Google Scholar 

  • Creda-Flores RM, Kshatriya GK, Bertin TK, Hewett-Emmett D, Hanis CL, Chakraborty R (1992) Genetic diversity and estimation of genetic admixture among Mexican-Americans of Starr County, Texas. Ann Hum Biol 19: 347–360

    Article  Google Scholar 

  • Chakraborty R, Jin L (1992) Heterozygote deficiency, population substructure and their implications in DNA fingerprinting. Hum Genet 88: 267–272

    Article  Google Scholar 

  • Chakraborty R, Kidd KK (1991) The utility of DNA typing in forensic work. Science 254: 1735–1739

    Article  Google Scholar 

  • Chakraborty R, DeAndrade M, Daiger SP, Budowle B (1992) Apparent heterozygote deficiencies observed in DNA typing data and their implications in forensic applications. Annals of Hum Genet 56: 45–57

    Article  Google Scholar 

  • Chakraborty R, Jin L, Zhong Y, Srinivasan MR, Budowle B (1993) On allele frequency computation from DNA typing data. Int J Leg Med (in press)

    Google Scholar 

  • Chakraborty R, Kamboh MI, Nwankwo M, Ferrell RE (1992a) Caucasian genes in American blacks. Am J Hum Genet 50: 145–155

    Google Scholar 

  • Chakraborty R, Srinivasan MR, Daiger SP (1993) Evaluation of standard error and confidence interval of estimated multilocus genotype probabilities and their implications in DNA forensics. Am J Hum Genet 52: 60–70

    Google Scholar 

  • Devlin B, Risch N (1992) A note on Hardy-Weinberg equilibrium of VNTR data using the FBI’s fixed bin method. Am J Hum Genet 51: 549–553

    Google Scholar 

  • Devlin B, Risch N (1992a) Ethnic differentiation at VNTR loci, with special reference to forensic applications. Am J Hum Genet 51: 534–548

    Google Scholar 

  • Devlin B, Risch N, Roeder K (1992) Forensic inference from DNA fingerprints. J Am Statist Ass 87: 337–350

    Article  Google Scholar 

  • Evett IW, Gill P (1991) A discussion of the robustness of methods for assessing the evidental value of DNA single locus profiles in crime investigation. Electrophoresis 12: 226–230

    Article  Google Scholar 

  • Evett IW, Pinchin R (1991) DNA single locus profiles: tests for the robustness of statistical procedures within the context of forensic science. Int J Legal Medicine 104: 267–272

    Article  Google Scholar 

  • Lewontin RC (1972) The apportionment of human diversity. Evol Biol 6: 381–398

    Article  Google Scholar 

  • Lewontin RC, Hartl DL (1991) Population genetics in forensic DNA typing. Science 254: 1745–1750

    Article  Google Scholar 

  • Monson KL, Budowle B (1993) VNTR population frequency estimation for forensics: effects of reference population and calculation method. J Forens Sci (in press)

    Google Scholar 

  • National Research Council (1992) DNA typing: statistical bases for interpretation. In: DNA Technology in Forensic Science, Chapter 3, Washington, D.C., National Academy Press, pp 74–96

    Google Scholar 

  • Reed TE (1969) Caucasian genes in American Negroes. Science 165: 762–768

    Article  Google Scholar 

  • Risch N, Devlin B (1992) On the probability of matching DNA fingerprints. Science 255: 717–720

    Article  Google Scholar 

  • Weir BS (1992) Independence of VNTR alleles defined by fixed bins. Genetics 130: 873–887

    Google Scholar 

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© 1993 Springer Basel AG

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Budowle, B., Monson, K.L. (1993). The forensic significance of various reference population databases for estimating the rarity of variable number of tandem repeat (VNTR) loci profiles. In: Pena, S.D.J., Chakraborty, R., Epplen, J.T., Jeffreys, A.J. (eds) DNA Fingerprinting: State of the Science. Progress in Systems and Control Theory. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8583-6_15

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  • DOI: https://doi.org/10.1007/978-3-0348-8583-6_15

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-7643-2906-8

  • Online ISBN: 978-3-0348-8583-6

  • eBook Packages: Springer Book Archive

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