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Reactive oxygen species and the regulation of metalloproteinase expression

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Free Radicals and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Irreparable degradation of articular cartilage is a characteristic feature of arthritic diseases and much of this degradation occurs as a result of increased levels of matrix metalloproteinases (MMPs) such as collagenase and stromelysin [1-6]. The elevated levels of degradative enzymes are due to increased synthesis by cells in joint tissue such as chondrocytes and synoviocytes, as well as invading cells, such as macrophages and neutrophils [7-9]. Thus, depending on the type of joint disease, several cell types may be involved in promoting cartilage destruction. In osteoarthritic cartilage, there is a marked depletion of matrix around the chondrocyte suggesting that this cell plays a key role in cartilage degradation. In inflammatory arthritis, both resident cells, synoviocytes and chondrocytes, as well as invading inflammatory cells are involved.

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Authors and Affiliations

  1. Connective Tissue Research Group, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, M5G 1X5, Ontario, Toronto, Canada

    Yvonne Y. C. Lo, Wing-Fai Cheung & Tony F. Cruz

  2. Department of Cellular and Molecular Pathology, University of Toronto, M5S 1A8, Ontario, Canada

    Yvonne Y. C. Lo, Wing-Fai Cheung & Tony F. Cruz

  3. Banting and Best Department of Medical Research, University of Toronto, M5G 1L6, Toronto, Ontario, Canada

    Johnson M. S. Wong

  4. Department of Molecular and Medical Genetics, University of Toronto, M5G 1L6, Toronto, Ontario, Canada

    Johnson M. S. Wong

Authors
  1. Yvonne Y. C. Lo
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  2. Johnson M. S. Wong
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  3. Wing-Fai Cheung
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  4. Tony F. Cruz
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Editor information

Editors and Affiliations

  1. St. Bartholomew’s and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 25-29 Ashfield Street, London, E1 1AD, UK

    Paul G. Winyard

  2. School of Postgraduate Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK

    David R. Blake

  3. Musculoskeletal Institute, University of Pittsburgh School of Medicine, 986 Scaife Hall, Pittsburgh, 15261, PA, USA

    Christopher H. Evans

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© 2000 Springer Basel AG

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Lo, Y.Y.C., Wong, J.M.S., Cheung, WF., Cruz, T.F. (2000). Reactive oxygen species and the regulation of metalloproteinase expression. In: Winyard, P.G., Blake, D.R., Evans, C.H. (eds) Free Radicals and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8482-2_10

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  • DOI: https://doi.org/10.1007/978-3-0348-8482-2_10

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9586-6

  • Online ISBN: 978-3-0348-8482-2

  • eBook Packages: Springer Book Archive

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