Abstract
Theophylline has been in clinical use for more than a century, although it is only during the last 50 years that this drug has been in regular use for the treatment of asthma. Theophylline was first used in the treatment of asthma in 1937, when it was administered i.v. for the treatment of acute asthma. In 1940, theophylline was first used orally in combination with ephedrine, and there are now many studies in the literature describing the effects of theophylline in the treatment of asthma [1]. Theophylline is now most commonly used in various slow-release formulations to overcome its rapid metabolism. However, over the last decade, the number of prescriptions being written for theophylline has declined, as newer medications have been introduced for the treatment of asthma, and this decline has come about mainly due to concerns about the narrow therapeutic window of theophylline, which has typically been classified as being 10-20.μg/ml in plasma [1].
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Page, C.P., Costello, J. (2000). Theophylline and New Generation Phosphodiesterase Inhibitors in the Treatment of Asthma. In: Giembycz, M.A., O’Connor, B.J. (eds) Asthma: Epidemiology, Anti-Inflammatory Therapy and Future Trends. Respiratory Pharmacology and Pharmacotherapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8480-8_10
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