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Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model

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Gene Therapy in Inflammatory Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

In the past few years there has been a growing interest in gene therapy to be used not only for the treatment of inherited, but also acquired, diseases. Although genetic factors have been frequently implicated in the pathogenesis of rheumatoid arthritis (RA) [1], and recent reports suggest mutations of tumor suppressor genes to play a role [2], RA is not caused by a specific genetic mutation. Much more likely it is an acquired disorder with a complex pathogenesis and yet unknown etiology. Gene therapy approaches in diseases such as RA differ from those in defined genetic disorders. Apart from the problem of how to correct a specific genetic abnormality, in RA another question appears to be crucial: that of which pathogenic pathway to modulate. Therefore, a suitable animal model for gene therapy approaches in RA should not only reflect relevant features of human disease but also permit one to analyze alterations in key disease processes as closely as possible to the conditions found in people.

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Author information

Authors and Affiliations

  1. Center for Experimental Rheumatology, Department of Rheumatology, University Hospital, 8091, Zürich, Switzerland

    Thomas Pap, Renate E. Gay & Steffen Gay

  2. Department of Internal Medicine I, Division of Clinical Rheumatology and Immunology, University of Regensburg, 93042, Regensburg, Germany

    Ulf Müller-Ladner

  3. Department of Internal Medicine, University of Göttingen, 37075, Göttingen, Germany

    Klaus M. Hummel

Authors
  1. Thomas Pap
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  2. Ulf Müller-Ladner
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  3. Klaus M. Hummel
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  4. Renate E. Gay
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  5. Steffen Gay
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Editors and Affiliations

  1. Center for Molecular Orthopaedics, Harvard Medical School, 221 Longwood Avenue, Room BL 152, Boston, MA, 02115, USA

    Christopher H. Evans

  2. University of Pittsburgh School of Medicine, W1246, Biological Sciences Tower, Pittsburgh, PA, 15261, USA

    Paul D. Robbins

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© 2000 Springer Basel AG

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Pap, T., Müller-Ladner, U., Hummel, K.M., Gay, R.E., Gay, S. (2000). Cartilage erosion in rheumatoid arthritis: studies in SCID mouse model. In: Evans, C.H., Robbins, P.D. (eds) Gene Therapy in Inflammatory Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8478-5_3

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  • DOI: https://doi.org/10.1007/978-3-0348-8478-5_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9584-2

  • Online ISBN: 978-3-0348-8478-5

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