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DNA vaccination as an anti-inflammatory strategy

  • Chapter
Gene Therapy in Inflammatory Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Vaccination has become a paradigm of preventative medicine, as it is both efficacious and cost-effective. The ability of vaccines to elicit specific immune responses is the key to their efficacy. There are two methods by which vaccines elicit immune responses. The first vaccines developed consisted of live attenuated pathogens which infect the host and stimulate a protective immune response. This includes the smallpox vaccine and the Sabin polio vaccine. The second method of vaccination was the development of killed pathogens or subunits. This includes the Salk polio vaccine (killed polio virus) and the hepatitis vaccine (recombinant surface antigen glycoprotein). These killed and subunit preparations have been also of great utility.

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Authors and Affiliations

  1. Department of Medicine, Divisions of Rheumatology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Alexis Paul Godillot & William V. Williams

  2. Department of Medicine, Divisions of Nephrology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Michael Madaio

  3. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    David B. Weiner

  4. Institute for Biotechnology and Advanced Molecular Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    David B. Weiner & William V. Williams

  5. Children’s Hospital of Philadelphia, 913 Stellar-Chance Laboratories, 422 Curie Drive, Philadelphia, PA, 19104-6100, USA

    William V. Williams

Authors
  1. Alexis Paul Godillot
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  2. Michael Madaio
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  3. David B. Weiner
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  4. William V. Williams
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Editors and Affiliations

  1. Center for Molecular Orthopaedics, Harvard Medical School, 221 Longwood Avenue, Room BL 152, Boston, MA, 02115, USA

    Christopher H. Evans

  2. University of Pittsburgh School of Medicine, W1246, Biological Sciences Tower, Pittsburgh, PA, 15261, USA

    Paul D. Robbins

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© 2000 Springer Basel AG

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Godillot, A.P., Madaio, M., Weiner, D.B., Williams, W.V. (2000). DNA vaccination as an anti-inflammatory strategy. In: Evans, C.H., Robbins, P.D. (eds) Gene Therapy in Inflammatory Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8478-5_11

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  • DOI: https://doi.org/10.1007/978-3-0348-8478-5_11

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9584-2

  • Online ISBN: 978-3-0348-8478-5

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