Abstract
Recent advances in our understanding of the mediators involved in acute and chronic inflammatory diseases have led to new strategies in the search for effective therapeutics. Traditional approaches include direct target intervention such as the use of specific antibodies, receptor antagonists, or enzyme inhibitors. Breakthroughs in the knowledge of regulatory mechanisms involved in the transcription and translation of inflammatory mediators has led to increased interest in therapeutic approaches directed at the level of gene transcription. Of the transcription factors targeted for pharmacological intervention, NF-кB has drawn much interest in light of its role as a coordinating regulator in the expression of a variety of rapid-response genes involved in inflammatory and immune reactions. The activation of NF-кB, its migration to the nucleus, and its binding to DNA provide numerous potential points of intervention, some of which are discussed below.
Keywords
- Therapeutic Promise
- Dominant Negative Inhibitor
- Tumor Necrosis Factor Stimulation
- Tumor Necrosis Factor Receptor Associate
- Rheumatoid Synoviocytes
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Chabot-Fletcher, M. (2000). Cellular signaling to NF-кB: Role in inflammation and therapeutic promise. In: Letts, L.G., Morgan, D.W. (eds) Inflammatory Processes:. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8468-6_3
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