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Immunology and Drug Therapy of Allergic Skin Diseases pp 1–13Cite as

Birkhäuser

Skin immune system (SIS)

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The immune system is complex and as a result, its dysregulations are even more difficult to understand. Atopy is a syndrome with apparent immune dysregulation. And so are atopic skin diseases, especially atopic dermatitis or eczema [1, 2]. Knowledge of normal immune function is necessary in order to understand aberrations such as atopy. This also is true for the skin where a good understanding of atopic skin diseases is only possible with adequate knowledge of the normal immune function of skin. In this chapter, the skin immune system (SIS) will be described. The SIS embodies the set of immune-response associated cellular and molecular elements of the human integument. Together they act as the physiological immune defense system of skin. There are numerous dysregulations of SIS. Those abnormalities in atopic skin diseases that can be directly related to the components of SIS will be referred to.

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Author information

Authors and Affiliations

  1. Department of Dermatology A0-235, Academic Medical Center, University of Amsterdam, P.O. Box 22700, Amsterdam, DE, 1100, Netherlands

    Jan D. Bos

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  1. Jan D. Bos
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Editors and Affiliations

  1. Department of Dermatology, University Hospital Utrecht, Heidelberglaan 100, Utrecht, CX, NL-3584, Netherlands

    C. A. F. M. Bruijnzeel-Koomen  & E. Knol  & 

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© 2000 Springer Basel AG

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Bos, J.D. (2000). Skin immune system (SIS). In: Bruijnzeel-Koomen, C.A.F.M., Knol, E. (eds) Immunology and Drug Therapy of Allergic Skin Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8464-8_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8464-8_1

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9579-8

  • Online ISBN: 978-3-0348-8464-8

  • eBook Packages: Springer Book Archive

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