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New Cytokines as Potential Drugs pp 121–138Cite as

Birkhäuser

Chemokines

  • Conference paper

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The immune system is comprised of many cell types which constantly migrate. This characteristic is essential for the defense of the organism against foreign agents, and for reparative processes such as wound healing. Insufficient recruitment and activation of leukocytes leads to inefficient clearance of pathogens. Conversely, their over-activation or unregulated recruitment leads to pathological damage, such as that seen in ischemia-reperfusion conditions of the myocardium and brain, and in the joints of patients with rheumatoid arthritis. Unfortunately, these conditions are not yet satisfactorily treated. Thus, it would be highly desirable to develop therapeutic agents that interfere with unregulated trafficking and activation of leukocytes. To this end, it is necessary to understand the mechanisms associated with normal leukocyte physiology. This field has advanced considerably in the last two decades and a number of key molecular regulators have been identified. Among these are the chemokines, a large family of molecules that mediate trafficking and other physiological parameters of leukocyte biology (for review see Rollins [1] and Zlotnik et al. [2]). As of 1998, over 40 chemokine ligands and 15 different receptors have been identified, and it is estimated that many new molecules remain to be discovered. Originally identified as molecules capable of inducing chemotaxis in vitro, chemokines are currently being subjected to intense experimental scrutiny. A combination of approaches, including genetic techniques, have demonstrated that chemokines have functions relating not only to leukocyte trafficking, but also to angiogenesis, hematopoiesis and development.

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Authors and Affiliations

  1. Department of Immunology, Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, USA

    Sergio A. Lira, Paul J. Zavodny & Daniel Lundell

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  1. Sergio A. Lira
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  2. Paul J. Zavodny
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  3. Daniel Lundell
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Editors and Affiliations

  1. Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033, USA

    Satwant K. Narula

  2. DNAX Research Institute, 901 California Avenue, Palo Alto, CA, 94304, USA

    Robert Coffman

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Lira, S.A., Zavodny, P.J., Lundell, D. (2000). Chemokines. In: Narula, S.K., Coffman, R. (eds) New Cytokines as Potential Drugs. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8456-3_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8456-3_8

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