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Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins pp 29–34Cite as

Birkhäuser

Regulation of the aspartate and alanine aminotransferases in humans and rodents

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Summary

We have studied the regulation of transaminase gene expression by hormones and drugs in humans and rodents. In rodents, most of the regulation is hormonal and is consistent with the role of these enzymes in gluconeogenesis.In humans, these genes are up-regulated by drugs such as fibrates, which may partially account for the increase in the activities in serum observed in some treated patients. Interestingly, fibrates down-regulate these genes in the rat, suggestingthat there ae important differences in the regulation of gene expression between rodents and humans.

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Author information

Authors and Affiliations

  1. Unité INSERM 490, Centre Universitaire des Saints-Péres, 45 rue des Saints-Pères, Paris, 75006, France

    Martine Aggerbeck, Fadéla Beurton, Céline Tomkiewicz, Michéle Garlatti, FranÇoise Muzeau & Robert Barouki

  2. CEREMOD,CNRS, 9 rue Jules Hetzel, Meudon, 92190, France

    Emmanuelle PléeGautier, Bénédicte Antoine & Claude Forest

Authors
  1. Martine Aggerbeck
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  2. Fadéla Beurton
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  3. Céline Tomkiewicz
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  4. Michéle Garlatti
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  5. FranÇoise Muzeau
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  6. Robert Barouki
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  7. Emmanuelle PléeGautier
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  8. Bénédicte Antoine
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  9. Claude Forest
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Editor information

Editors and Affiliations

  1. Division of Molecular Biology and Biochemistry School of Biological Sciences, University of Missouri, Kansas City, MO, 64110, USA

    Ana Iriarte  & Marino Martinez-Carrion  & 

  2. Department of Biochemistry, Boston University School of Medicine, 80E Concord Street, Boston, MA, 02118-2394, USA

    Herbert M. Kagan

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© 2000 Springer Basel AG

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Aggerbeck, M. et al. (2000). Regulation of the aspartate and alanine aminotransferases in humans and rodents. In: Iriarte, A., Martinez-Carrion, M., Kagan, H.M. (eds) Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8397-9_5

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  • DOI: https://doi.org/10.1007/978-3-0348-8397-9_5

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9549-1

  • Online ISBN: 978-3-0348-8397-9

  • eBook Packages: Springer Book Archive

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