Summary
Ornithine decarboxylase (ODC) is up regulated in cells in response to activating stimuli. We now show that the initial cytosolic increase of ODC is followed by the translocation of a fraction of the enzyme to the surface membrane. The ODC membrane translocation is mediated by a p47phox membrane-targeting motif-related sequence that has the protein kinase C phosphorylation consensus motif. The motif-mediated translocation of ODC is of fundamental importance for its biologic function.
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Heiskala, M., Zhang, J., Hayashi, Si., Hölttä, E., Andersson, L.C. (2000). Activation and transformation of cells induce translocation of ornithine decarboxylase (ODC) to the surface membrane. In: Iriarte, A., Martinez-Carrion, M., Kagan, H.M. (eds) Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8397-9_37
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DOI: https://doi.org/10.1007/978-3-0348-8397-9_37
Publisher Name: Birkhäuser, Basel
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