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Cholinergic and noncholinergic parasympathetic control of airway smooth muscle

  • Chapter
Book cover Muscarinic Receptors in Airways Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

In mammals, including humans, drugs that block cholinergic muscarinic receptors cause significant and, in some cases, near maximal bronchodilation [1-3]. Moreover, in animal studies, the bronchodilating effect of the anticholinergic drugs can be mimicked by sectioning the right and left vagus nerves [4,5]. Considered together, these observations support the hypothesis that the parasympathetic branch of the autonomic nervous system is the major regulator of mammalian airway smooth muscle tone.

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References

  1. Widdicombe JG, Nadel JA (1963) Airway volume, airway resistance, and work and force of breathing: Theory. J Appl Physiol 18: 863–868

    PubMed  CAS  Google Scholar 

  2. Coleridge HM, Coleridge JCG, Schultz HD (1989) Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmacol Ther 42: 1–63

    Article  PubMed  CAS  Google Scholar 

  3. Severinghaus JW, Stupfel M (1955) Respiratory dead space increase following atropine in man, and atropine, vagal or ganglionic blockade and hypothermia in dogs. J Appl Physiol 8: 81–87

    PubMed  CAS  Google Scholar 

  4. Colebatch H, Halmagyi F (1963) Effect of vagotomy and vagal stimulation on lung mechanics and circulation. J Appl Physiol 18: 881–887

    PubMed  CAS  Google Scholar 

  5. Olsen CR, Colebatch HJH, Mebel PE, Nadel JA, Staub NC (1965) Motor control of pulmonary airways studied by nerve stimulation. J Appl Physiol 20: 202–208

    Google Scholar 

  6. Widdicombe JG, Wells UM (1994) Vagal reflexes. In: D Raeburn, M Gymbiecz (eds): Airways smooth muscle: structure innervation and neurotransmission. Springer Basel AG, Basel, 279–307

    Google Scholar 

  7. Kalia M (1987) Organization of central control of airways. Ann Rev Physiol 49:595–609

    Article  CAS  Google Scholar 

  8. Skoogh B-E (1988) Airway parasympathetic ganglia. In: MA Kaliner, PJ Barnes: The air-ways neural control in health and disease. Marcel Dekker, New York, Basel, 217–240

    Google Scholar 

  9. Dey RD (1995) Airways ganglia. In: D Raeburn, M. Gymbiecz (eds): Airways smooth muscle: structure innervation and neurotransmission. Springer Basel AG, Basel, 79–101

    Google Scholar 

  10. Undem BJ, Myers AC (1997) Autonomic ganglia. In: PJ Barnes: Autonomic control of the respiratory system. Harwood Academic Publishers, Amsterdam, 87–117

    Google Scholar 

  11. Barnes PJ (1992) Modulation of neurotransmission in airways. Physiol Rev 72: 699–729

    PubMed  CAS  Google Scholar 

  12. Black JL (1997) Innervation of airway smooth muscle. In: PJ Barnes: Autonomic control of the respiratory system. Harwood Academic Publishers, Amsterdam, 185–200

    Google Scholar 

  13. Kalia M (1981) Brain stem localization of vagal preganglionic neurons. J Auton Nery Syst 3: 451–481

    Article  CAS  Google Scholar 

  14. Kerr FWL (1969) Preserved vagal visceromotor function following destruction of the dorsal motor nucleus. J Physiol 202: 755–769

    PubMed  CAS  Google Scholar 

  15. Haselton JR, Solomon KC, Motekaitis AM, Kaufman MP (1992) Bronchomotor vagal preganglionic cell bodies in the dog: an anatomic and functional study. J Appl Physiol 73: 1122–1129

    PubMed  CAS  Google Scholar 

  16. Kalia M, Mesulam M-M (1980) Brain stem projections of sensory and motor components of the vagus complex in the cat: II Laryngeal, tracheobronchial pulmonary, cardiac, and gastrointestinal branches. J Comp Neurol 193: 467–508, 1980

    Article  PubMed  CAS  Google Scholar 

  17. Haxhiu MA, Loewy AD (1996) Central connections of the motor and sensory vagal systems innervating the trachea. J Auton Nery Syst 57: 49–56

    Article  CAS  Google Scholar 

  18. Perez-Fontan JJ, Velloff CR (1997) Neuroanatomic organization of the parasympathetic bronchomotor system in developing sheep. Am J Physiol 273: 121–133

    Google Scholar 

  19. Jammes Y, Fornaris E, Mei N, Barrat E (1982) Afferent and efferent components of the bronchial vagal branches in cats. J Auton Nery Syst 5: 165–176

    Article  CAS  Google Scholar 

  20. Evans DHL, Murray JG (1954) Histological and functional studies on the fibre composition of the vagus nerve of the rabbit. J Anat 88: 320–337

    PubMed  CAS  Google Scholar 

  21. Agostoni E, Chinnock JE, DeBurgh-Daly M, Murray JG (1957) Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J Physiol 135: 182–205

    PubMed  CAS  Google Scholar 

  22. Widdicombe JG (1988) Vagal reflexes in the airways. In: MA Kaliner, PJ Barnes: The airways neural control in health and disease. Marcel Dekker, New York, Basel, 187–202

    Google Scholar 

  23. Ellis JL, Undem BJ (1994) Pharmacology of non-adrenergic, non-cholinergic nerves in airway smooth muscle. Pulm Pharmacol 7: 205–223

    Article  PubMed  CAS  Google Scholar 

  24. Canning BJ, Undem BJ (1993) Capsaicin-sensitive afferents activate neurons mediating NANC relaxations of the guinea pig trachealis: Possible involvement of tachykinins. FASEB J 7: A6863

    Google Scholar 

  25. Lama A, Delpierre S, Jammes Y (1988) The effects of electrical stimulation of myelinated and non-myelinated vagal motor fibres on airway tone in the rabbit and the cat. Respir Physiol 74: 265–274

    Article  PubMed  CAS  Google Scholar 

  26. Mitchell RA, Herbert DA, Baker DG, Basbaum CB (1987) In vivo activity of tracheal parasympathetic ganglion cells innervating tracheal smooth muscle. Brain Res 437: 157–160

    Article  PubMed  CAS  Google Scholar 

  27. Widdicombe JG (1966) Action potentials in parasympathetic and sympathetic efferent fibres to the trachea and lungs of dogs and cats. J Physiol 186: 56–88

    PubMed  CAS  Google Scholar 

  28. McAllen RM, Spyer KM (1978) Two types of vagal preganglionic motoneurones projecting to the heart and lungs. J Physiol 282: 353–364

    PubMed  CAS  Google Scholar 

  29. Leblanc PH, Buckner CK, Brunson DB, Laravuso RB, Will JA (1987) Differential effect of ketamine on cholinergic-and noncholinergic-induced contractions of isolated guinea-pig bronchi. Arch Int Pharmacodyn Ther 287: 120–132

    PubMed  CAS  Google Scholar 

  30. Canning BJ, Undem BJ (1994) Parasympathetic innervation of airways smooth muscle. In: D Raeburn, M Gymbiecz (eds): Airways smooth muscle: structure innervation and neurotransmission. Springer Basel AG, Basel, 43–78

    Google Scholar 

  31. Jammes Y, Mei N (1979) Assessment of the pulmonary origin of bronchoconstrictor vagal tone. J Physiol 291: 305–316

    PubMed  CAS  Google Scholar 

  32. Kesler BS, Canning BJ (1999) Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle. J Physiol 518.3: 843–855

    Article  Google Scholar 

  33. Sherrington SC (1906) The integrative action of the nervous system. Yale University Press, New Haven, 49–102

    Google Scholar 

  34. Karlsson J-A, Sant’Ambrogio G, Widdicombe JG (1988) Afferent neural pathways in cough and reflex bronchoconstriction. J Appl Physiol 65: 1007–1023

    PubMed  CAS  Google Scholar 

  35. Kaufman J, Wright GW (1969) The effect of nasal and nasopharyngeal irritation on airway resistance in man. Am Rev Respir Dis 100: 626–630

    PubMed  CAS  Google Scholar 

  36. Nolte D, Berger D (1983) On vagal bronchoconstriction in asthmatic patients by nasal irritation. Eur J Respir Dis 64: 110–114

    Google Scholar 

  37. Szarek JL, Gillespie MN, Altiere RJ, Diamond L (1986) Reflex activation of the nonadrenergic noncholinergic inhibitory nervous system in feline airways. Am Rev Respir Dis 133: 1159–1162

    PubMed  CAS  Google Scholar 

  38. Michoud M-C, Jeanneret-Grosjean A, Cohen A, Amyot R (1988) Reflex decrease of histamine-induced bronchoconstriction after laryngeal stimulation in asthmatic patients. Am Rev Respir Dis 138: 1548–1552

    PubMed  CAS  Google Scholar 

  39. Lammers J-W, Minette P, McCusker MT, Chung KF, Barnes PJ (1988) Nonadrenergic bronchodilator mechanisms in normal human subjects in vivo. J Appl Physiol 64: 1817–1822

    CAS  Google Scholar 

  40. Haxhiu MA, Jansen AS, Nerniack NS, Loewy AD (1993) CNS innervation of airway-related parasympathetic prrganglionic neurons: a transneuronal labeling study using pseudorabies virus. Brain Res 618: 115–134

    Article  PubMed  CAS  Google Scholar 

  41. Haxhiu MA, Erokwu B, Dreshaj IA (1997) The role of excitatory amino acids in airway reflex responses in anesthetized dogs. J Auton Nery Syst 67: 192–199

    Article  CAS  Google Scholar 

  42. Haxhiu MA, Erokwu B, Bhardwaj V, Dreshaj IA (1998) The role of the medullary raphe nuclei in regulation of cholinergic outflow to the airways. J Auton Nery Syst 69: 64–71

    Article  CAS  Google Scholar 

  43. Haxhiu MA, Deal EC, van Lunteren E, Cherniack NS (1989) Central modulatory effects of tachykinin peptides on airway tone. J Auton Nery Syst 28: 105–115

    Article  CAS  Google Scholar 

  44. Haxhiu MA, Dreshaj IA, McFadden CB, Erokwu BO, Ernsberger P (1998) I1-imidazoline receptors and cholinergic outflow to the airways. J Auton Nery Syst 71: 167–174

    Article  CAS  Google Scholar 

  45. Richardson J, Beland J (1976) Nonadrenergic inhibitory nervous system in human airways. J Appl Physiol 41: 764–771

    PubMed  CAS  Google Scholar 

  46. Dey RD, Altemus JB, Michalkiewicz M (1991) Distribution of vasoactive intestinal peptide-and substance P-containing nerves originating from neurons of airway ganglia in cat bronchi. J Comp Neurol 304: 330–340

    Article  PubMed  CAS  Google Scholar 

  47. Fisher WF (1964) The intrinsic innervation of the trachea. J Anat Lond 98: 117–124

    CAS  Google Scholar 

  48. Larsell O (1923) The ganglia, plexuses, and nerve-terminations of the mammalian lung and pleura pulmonalis. J Comp Neurol 35: 97–132

    Article  Google Scholar 

  49. Myers AC, Undem BJ, Kummer W (1996) Anatomical and electrophysiological comparison of the sensory innervation of bronchial and tracheal parasympathetic ganglion neurons. J Auton Nery Syst 61: 162–168

    Article  CAS  Google Scholar 

  50. Lees GM, Pacitti EG, Mackenzie GM (1997) Morphology and electrophysiology of guinea-pig paratracheal neurones. Anat Rec 247: 261–270

    Article  PubMed  CAS  Google Scholar 

  51. Baker DG, Basbaum CB, Herbert DA, Mitchell RA (1983) Transmission in airway ganglia of ferrets: inhibition by norepinephrine. Neurosci Lett 41: 139–143

    Article  PubMed  CAS  Google Scholar 

  52. Cameron AR, Coburn RF (1984) Electrical and anatomic characteristics of cells of ferret paratracheal ganglion. Am J Physiol 246: C450–C458

    PubMed  CAS  Google Scholar 

  53. Coburn RF, Kalia MP (1986) Morphological features of spiking and nonspiking cells in the paratracheal ganglion of the ferret. J Comp Neurol 254: 341–351

    Article  PubMed  CAS  Google Scholar 

  54. Aibara K, Akaike N (1991) Acetylcholine-activated ionic currents in isolated paratracheal ganglion cells of the rat. Brain Res 558: 20–26

    Article  PubMed  CAS  Google Scholar 

  55. Allen TGJ, Burnstock G (1990) A voltage-clamp study of the electrophysiological characteristics of the intramural neurones of the rat trachea. J Physiol 423: 593–614

    PubMed  CAS  Google Scholar 

  56. Murai Y, Ishibashi H, Akaike N, Ito Y (1998) Acetylcholine modulation of high-voltage-activated calcium channels in the neurones acutely dissociated from rat paratracheal ganglia. Br J Pharmacol 123: 1441–1449

    Article  PubMed  CAS  Google Scholar 

  57. Myers AC, Undem BJ, Weinreich D (1990) Electrophysiological properties of neurons in guinea pig bronchial parasympathetic ganglia. Am J Physiol 259: L403–L409

    PubMed  CAS  Google Scholar 

  58. Myers AC (1997) Evidence for neural integration by human bronchial parasympathetic ganglia neurons. Am Rev Respir Grit Care Med 155: A575

    Google Scholar 

  59. Canning BJ, Undem BJ (1993) Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis. J Physiol 471: 25–40

    PubMed  CAS  Google Scholar 

  60. Canning BJ, Undem BJ, Karakousis PC, Dey RD (1996) Effects of organotypic culture on cholinergic and noncholinergic parasympathetic nerves innervating airway smooth muscle. Am J Physiol 271: L698–L706

    PubMed  CAS  Google Scholar 

  61. Fischer A, Canning BC, Undem BJ, Kummer W (1998) Evidence for an esophageal origin of VIP and NO synthase-ir nerves innervating the guinea pig trachealis: A retrograde neuronal tracing immunohistochemical analysis. J Compar Neurol 394: 326–334

    Article  CAS  Google Scholar 

  62. Moffatt JD, Dumsday B, McLean JR (1998) Non-adrenergic, non-cholinergic neurons innervating the guinea-pig trachea are located in the oesophagus: evidence from retrograde neuronal tracing. Neurosci Lett 248: 37–40

    Article  PubMed  CAS  Google Scholar 

  63. Dey RD, Altemus JB, Rodd A, Mayer B, Said SI, Coburn RF (1996) Neurochemical characterization of intrinsic neurons in ferret tracheal plexus. Am J Respir Cell Mol Biol 14: 207–216

    PubMed  CAS  Google Scholar 

  64. Myers AC (2000) Anatomical characteristics of tonic and phasic neurons in guinea pig bronchial parasympathetic ganglia. J Compar Neurol 419: 439–450

    Article  CAS  Google Scholar 

  65. McMahan UJ, Kuffler SW (1971) Visual identification of synaptic boutons on living ganglion cells and of varicosities in postganglionic axons in the heart of the frog. Proc Roy Soc Lond 177: 485–508

    Article  CAS  Google Scholar 

  66. Myers AC, Undem BJ (1991) Analysis of preganglionic nerve evoked cholinergic contractions of the guinea pig bronchus. J Auton Nery Sys 35: 175–184

    Article  CAS  Google Scholar 

  67. Canning BJ, Fischer A, Undem BJ (1998) Pharmacological analysis of the tachykinin receptors that mediate activation of nonadrenergic, noncholinergic relaxant nerves that innervate guinea pig trachealis. J Pharmacol Exp Ther 284: 370–377, 1998

    PubMed  CAS  Google Scholar 

  68. Lundberg JM, Hokfelt T, Martling C-R, Saria A, Cuello C (1984) Substance Pimmunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res 235: 251–261

    Article  PubMed  CAS  Google Scholar 

  69. Canning BJ, Undem BJ (1993) Evidence that the parasympathetic pathway mediating relaxation of guinea-pig trachealis is distinct from that mediating contraction. J Physiol 471: 25–40

    PubMed  CAS  Google Scholar 

  70. Myers AC, Undem BJ (1993) Electrophysiological effects of tachykinins and capsaicin on guinea-pig bronchial parasympathetic ganglion neurones. J Physiol 470: 665–679

    PubMed  CAS  Google Scholar 

  71. Myers AC, Undem BJ, Weinreich D (1991) Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. J Appl Physiol 71: 970–976

    PubMed  CAS  Google Scholar 

  72. Undem BJ, Myers AC, Weinreich D (1991) Antigen-induced modulation of autonomic and sensory neurons in vitro. Int Arch Allergy appl Immunol 94: 319–324

    Article  PubMed  CAS  Google Scholar 

  73. Myers AC (1998) Ca++and K+ currents underlying action potential accommodation by neurons in guinea pig bronchial parasympathetic ganglia. Am J Physiol Lung Cell Mol Phys L357–L364

    Google Scholar 

  74. Myers AC, Undem BJ (1995) Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors. Am J Phys (Lung Cell Mol Physiol) 12: L879–L884

    Google Scholar 

  75. Kajekar R, Myers AC (2000) Bradykinin stimulates guinea pig bronchial parasympathetic ganglia neurons independent of sensory nerve stimulation. Am J Physiol Lung Cell Mol Physiol 278: L485–L491

    PubMed  CAS  Google Scholar 

  76. McCaig DJ (1986) Electrophysiology of neuroeffector transmission in the isolated, innervated trachea of the guinea-pig. Br J Pharmacol 89: 793–801

    Article  PubMed  CAS  Google Scholar 

  77. Ichinose M, Barnes PJ (1989) Histamine H3-receptors modulate nonadrenergic noncholinergic neural bronchoconstriction in guinea-pig in vivo. Eur J Pharmacol 174: 49–55

    Article  PubMed  CAS  Google Scholar 

  78. Reekie FM, Burnstock G (1992) Effects of noradrenaline on rat paratracheal neurons and localization of an endogenous source of noradrenaline. Br J Pharmacol 107: 471–475

    Article  PubMed  CAS  Google Scholar 

  79. Myers AC, Undem BJ (1996) Muscarinic receptor regulation of synaptic transmission in airway parasympathetic ganglia. Am J Physiol 270: L630–L636

    PubMed  CAS  Google Scholar 

  80. Martin JG, Wang A, Zacour M, Biggs DF (1990) The effects of vasoactive intestinal polypeptide on cholinergic neurotransmission in isolated innervated guinea pig tracheal preparations. Respir Physiol 79: 111–122

    Article  PubMed  CAS  Google Scholar 

  81. Allen TGJ, Burnstock G (1990) GABAA receptor-mediated increase in membrane chloride conductance in rat paratracheal neurones. Br J Pharmacol 100: 261–268

    Article  PubMed  CAS  Google Scholar 

  82. Itabashi S, Aibara K, Sasaki H, Akaike N (1992) y-aminobutyric acid-induced response in rat dissociated paratracheal ganglion cells. J Neurophysiol 67: 1367–1374

    PubMed  CAS  Google Scholar 

  83. Gabella G (1992) Fine structure of post-ganglionic nerve fibres and autonomic neuroeffector junctions. In: G Burnstock, CHV Hoyle (eds): Autonomic neuroeffector mechanisms. Harwood Academic Publishers, Amsterdam, 1–31

    Google Scholar 

  84. Gabella G (1987) Innervation of airway smooth muscle: Fine structure. Ann Rev Physiol 49: 583–594

    Article  CAS  Google Scholar 

  85. Ellis JL, Undem BJ (1992) Inhibition by L-NG-nitro-L-arginine of nonadrenergic-noncholinergic-mediated relaxations of human isolated central and peripheral airways. Am Rev Respir Dis 146: 1543–1547

    PubMed  CAS  Google Scholar 

  86. Andersson RG, Grundstrom N (1987) Innervation of airway smooth muscle. Efferent mechanisms. Pharmacol Tiler 32: 107–130

    Article  CAS  Google Scholar 

  87. Ward JK, Barnes PJ, Springall DR, Abelli L, Tadjkarimi S, Yacoub MH, Polak JM, Belvisi MG (1995) Distribution of human i-NANC bronchodilator and nitric oxideimmunoreactive nerves. Am J Respir Cell Mol Biol 13: 175–184

    PubMed  CAS  Google Scholar 

  88. Grundstrom N, Andersson RGG, Wikberg JES (1981) Pharmacological characterization of the autonomic innervation of the guinea pig tracheobronchial smooth muscle. Acta Pharmacol Toxicol 49: 150–157

    Article  CAS  Google Scholar 

  89. Undem BJ, Myers AC, Barthlow H, Weinreich D (1990) Vagal innervation of the guinea pig bronchus. J Appl Physiol 69: 1336–1346

    PubMed  CAS  Google Scholar 

  90. Tucker JF, Brave SR, Charalambous L, Hobbs AJ, Gibson A (1990) L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol 100: 663–664

    Article  PubMed  CAS  Google Scholar 

  91. Kannan MS, Johnson DE (1992) Nitric oxide mediates the neural nonadrenergic, noncholinergic relaxation of pig tracheal smooth muscle. Am J Physiol 262: L511–L514

    PubMed  CAS  Google Scholar 

  92. Fisher JT, Anderson JW, Waldron MA (1993) Nonadrenergic noncholinergic neurotransmitter of feline trachealis: VIP or nitric oxide? J Appl Physiol 74: 31–39

    Article  PubMed  CAS  Google Scholar 

  93. Bai TR, Bramley AM (1993) Effect of an inhibitor of nitric oxide synthase on neural relaxation of human bronchia. Am J Physiol 264: L425–L430

    PubMed  CAS  Google Scholar 

  94. Belvisi MG, Stretton CD, Miura M, Verleden GM, Tadjkarimi S, Yacoub MH, Barnes PJ (1992) Inhibitory NANC nerves in human tracheal smooth muscle: a quest for the neurotransmitter. J Appl Physiol 73: 2505–2510

    PubMed  CAS  Google Scholar 

  95. Venugopalan CS, Said SI, Drazen JM (1984) Effect of vasoactive intestinal peptide on vagally mediated tracheal pouch relaxation. Respir Physiol 56: 205–216

    Article  PubMed  CAS  Google Scholar 

  96. Ellis JL, Farmer SG (1989) Effects of peptidases on non-adrenergic, non-cholinergic inhibitory responses of tracheal smooth muscle: a comparison with effects on VIP- and PHI-induced relaxation. Br J Pharmacol 96: 521–526

    Article  PubMed  CAS  Google Scholar 

  97. Diamond L, O’Donnell M (1980) A nonadrenergic vagal inhibitory pathway to feline airways. Science 208: 185–188

    Article  PubMed  CAS  Google Scholar 

  98. Chesrown SE, Venugopalan CS, Gold WM, Drazen JM (1980) In vivo demonstration of nonadrenergic inhibitory innervation of the guinea pig trachea. J Clin Invest 65: 314–320

    Article  PubMed  CAS  Google Scholar 

  99. Yip P, Palombini B, Coburn RF (1981) Inhibitory innervation to the guinea pig trachealis muscle. J Appl Physiol 50: 374–382

    PubMed  CAS  Google Scholar 

  100. Canning BJ, Undem BJ (1993) Relaxant innervation of the guinea-pig trachealis: Demonstration of capsaicin-sensitive and insensitive vagal pathways. J Physiol 460: 719–739

    PubMed  CAS  Google Scholar 

  101. Fischer A, Hoffman B (1996) Nitric oxide synthase in neurons and nerve fibers of lower airways and in vagal sensory ganglia of man. Am J Respir Crit Care Med 154: 209–216

    PubMed  CAS  Google Scholar 

  102. Fischer A, Canning BJ, Kummer W (1996) Correlation of vasoactive intestinal peptide and NO synthase with choline acetyltransferase in the airway innervation. Ann NY Acad Sci 805: 717–722

    Article  PubMed  CAS  Google Scholar 

  103. Canning BJ, Undem BJ, Karakousis PC, Dey RD (1996) Influence of organotypic culture on cholinergic and noncholinergic parasympathetic nerves innervating airway smooth muscle. Am J Phys (Lung Cell Mol Phys) 271: L698–L706

    CAS  Google Scholar 

  104. Barnes PJ (1994) Modulation of neurotransmitter release from airways nerves. In: D Raeburn, M Gymbiecz (eds): Airways smooth muscle: structure innervation and neurotransmission. Birkhäuser, Basel, 209–259

    Google Scholar 

  105. Fryer A (1997) The cholinergic control of the airways. In: PJ Barnes: Autonomic con- trol of the respiratory system. Harwood Academic Publishers, Amsterdam, 59–86

    Google Scholar 

  106. Aas P, Fonnum F (1986) Presynaptic inhibition of acetylcholine release. Acta Physiol Scand 127: 335–342

    Article  PubMed  CAS  Google Scholar 

  107. Yang Z-J, Biggs DF (1991) Muscarinic receptors and parasympathetic neurotransmission in guinea-pig trachea. Eur J Pharmacol 193: 301–308

    Article  PubMed  CAS  Google Scholar 

  108. Watson N, Barnes PJ, Maclagan J (1992) Action of methoctramine, a muscarinic M2receptor antagonist on muscarinic and nicotine cholinoceptors in guinea pig airways in vivo and in vitro. Br J Pharmacol 105: 107–112

    Article  CAS  Google Scholar 

  109. Doelman CJA, Sprong RC, Nagtegaal JE, Rodrigues-deMiranda JF, Bast A (1991) Pre-junctional muscarinic receptors on cholinergic nerves in guinea pig airways are of the M2 subtype. Eur J Pharmacol 193: 117–120

    Article  PubMed  CAS  Google Scholar 

  110. Minette PA, Barnes PJ (1988) Prejunctional inhibitory muscarinic recptors on cholinergic nerves in human and guinea-pig airways. J Appl Physiol 64: 2532–2537

    PubMed  CAS  Google Scholar 

  111. Patel HJ, Barnes PJ, Takahashi T, Tadjkarimi S, Yacoub MH, Belvisi MG (1995) Evi-dence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med 152: 872–878

    PubMed  CAS  Google Scholar 

  112. ten Berge RE, Zaagsma J, Roffel AF (1996) Muscarinic inhibitory autoreceptors in different generations of human airways. Am J Respir Crit Care Med 154: 43–49

    PubMed  Google Scholar 

  113. Roffel AF, Davids JH, Elzinga CR, Wolf D, Zaagsma J, Kilbinger H (1997) Characterization of the muscarinic recptor subtype(s) mediating contraction of the guinea-pig lung strip and inhibition of the guinea-pig lung strip and inhibition of acetylcholine release in the guinea-pig trachea with the selective muscarinic receptor antagonist tripitramine. Br J Pharmacol 122: 133–141

    Article  PubMed  CAS  Google Scholar 

  114. Fryer AD, Maclagan J (1984) Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol 83: 973–978

    Article  PubMed  CAS  Google Scholar 

  115. Blaber LC, Fryer AD, Maclagan J (1985) Neuronal muscarinic receptors attenuate vagally-induced contraction of feline bronchial smooth muscle. Br J Pharmacol 86: 723–728

    Article  PubMed  CAS  Google Scholar 

  116. Zhang XY, Robinson NE, Wang ZW, Lu MC (1995) Catecholamine affects acetylcholine release in trachea: alpha 2-mediated inhibition and beta-mediated augmentation. Am J Physiol 268: L368–L373

    PubMed  CAS  Google Scholar 

  117. Zhang XY, Zhu FX, Robinson NE (1996) Excitatory prejunctional beta 2-adrenoceptor distribution within equine airway cholinergic nerves. Respir Physiol 106: 81–90

    Article  PubMed  CAS  Google Scholar 

  118. Belvisi MG, Patel HJ, Takahashi T, Barnes PJ, Giembycz MA (1996) Paradoxical facilitation of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by isoprenaline. Br J Pharmacol 117: 1413–1420

    Article  PubMed  CAS  Google Scholar 

  119. Haas JR, Terpstra JS, van der Zwaag J, Kockelbergh PG, Roffel AF, Zaagsma J (1999) Facilitatory beta2-adrenoceptors on cholinergic and adrenergic nerve endings of the guinea pig trachea. Am J Physiol 276: L420–L425

    PubMed  Google Scholar 

  120. Vermeire PA, Vanhoutte PM (1979) Inhibitory effects of catecholamines in isolated canine bronchial smooth muscle. J Appl Physiol: Respirat Environ Exercise Physiol 46: 787–791

    CAS  Google Scholar 

  121. Danser AHJ, Ende RVD, Lorenz RR, Flavahan NA, Vanhoutte PM (1987) Prejunctional Bradrenoceptors inhibit cholinergic transmission in canine bronchi. J Appl Physiol 62: 785–790

    PubMed  CAS  Google Scholar 

  122. Rhoden KJ, Meldrum LA, Barnes PJ (1988) Inhibition of cholinergic neurotransmission in human airways by β2-adrenoceptors. J Appl Physiol 65: 700–705

    PubMed  CAS  Google Scholar 

  123. Wessler I, Reinheimer T, Brunn G, Anderson GP, Maclagan J, Racke K (1994) Betaadrenoceptors mediate inhibition of [3H]-acetylcholine release from the isolated rat and guinea-pig trachea: role of the airway mucosa and prostaglandins. Br J Pharmacol 113: 1221–1230

    Article  PubMed  CAS  Google Scholar 

  124. Grundstrom N, Andersson RGG, Wikberg JES (1981) Prejunctional α2-adrenoceptors inhibit contraction of tracheal smooth muscle by inhibiting cholinergic neurotransmission. Life Sci 28: 2981–2986

    Article  PubMed  CAS  Google Scholar 

  125. Thompson DC, Diamond L, Altiere RJ (1990) Presynaptic α-adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea. J Pharmac Exp Ther 254: 306–311

    CAS  Google Scholar 

  126. Thompson DC, Diamond L, Altiere RJ (1992) Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulm Pharmacol 5: 251–255

    Article  PubMed  CAS  Google Scholar 

  127. Tanaka DT, Grunstein MM (1984) Mechanisms of substance P-induced contraction of rabbit airway smooth muscle. J Appl Physiol: Respirat Environ Exercise Physiol 57: 1551–1557

    CAS  Google Scholar 

  128. Belvisi MG, Patacchini R, Barnes PJ, Maggi CA (1994) Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences. Br J Pharmacol 111: 103–110

    Article  PubMed  CAS  Google Scholar 

  129. Hey JA, Danko G, del Prado M, Chapman RW (1996) Augmentation of neurally evoked cholinergic bronchoconstrictor responses by prejunctional NK2 receptors in the guinea-pig. J Auton Pharmacol 16: 41–48

    Article  PubMed  CAS  Google Scholar 

  130. Belvisi MG, Stretton CD, Verleden GM, Ledingham SJ, Yacoub MH, Barnes PJ (1992) Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol 72: 1096–1100

    Article  PubMed  CAS  Google Scholar 

  131. Patel HJ, Giembycz MA, Spicuzza L, Barnes PJ, Belvisi MG (1997) Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin. Br J Pharmacol 120: 735–736

    Article  PubMed  CAS  Google Scholar 

  132. Stretton CD, Barnes PJ (1988) Modulation of cholinergic neurotransmission in guinea-pig trachea by neuropeptide Y. Br J Pharmacol 93: 672–678

    Article  PubMed  CAS  Google Scholar 

  133. Grundemar WE, Waldeck B, Hakanson R (1988) Neuropeptide Y: prejunctional inhibition of vagally-induced contraction in the guinea pig trachea. Regul Peptides 23: 309–314

    Article  CAS  Google Scholar 

  134. Barnes PJ (1997) Neuromodulation in airways. In: G Burnstock (ed): Autonomic control of the respiratory system. Harwood Academic Publishers, Amsterdam, 139–184

    Google Scholar 

  135. Shore S, Collier B, Martin JG (1987) Effect of endogenous prostaglandins on acetylcholine release from dog trachealis muscle. J Appl Physiol 62: 1837–1844

    Article  PubMed  CAS  Google Scholar 

  136. Black JL, Johnson PRA, Alfredson M, Armour CL (1989) Inhibition by prostaglandin E2 of neurotransmission in rabbit but not human bronchus — a calcium related mechanism? Prostaglandins 37: 317–330

    Article  PubMed  CAS  Google Scholar 

  137. Spicuzza L, Giembycz MA, Barnes PJ, Belvisi MG (1998) Prostaglandin E2 suppression of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by interacting with prostanoid receptors of the EP3-subtype. Br J Pharmacol 123: 1246–1252

    Article  PubMed  CAS  Google Scholar 

  138. Leff AR, Munz NM, Tallet J, Cavigelli M, David AC (1985) Augmentation of parasympathetic contraction in tracheal and bronchial airways by prostaglandins F2αin vitro. J Appl Physiol 58: 1558–1664

    CAS  Google Scholar 

  139. Tamaoki J, Sekizawa K, Graf PD, Nadel JA (1987) Cholinergic neuromodulation by prostaglandin D2 in canine airway smooth muscle. J Appl Physiol 63: 1396–1400

    PubMed  CAS  Google Scholar 

  140. Chung KF, Evans TW, Graf PD, Nadel JA (1985) Modulation of cholinergic neuro-transmission in canine airways by thromboxane mimetic U46619. Eur J Pharmacol 117: 373–375

    Article  PubMed  CAS  Google Scholar 

  141. Inoue T, Ito Y (1985) Pre-and post-junctional actions of prostaglandin 12, carbocyclic thromboxane A2 and leukotriene C4 in dog tracheal tissue. Br J Pharmacol 84: 289–298

    Article  PubMed  CAS  Google Scholar 

  142. Takahashi T, Ward JK, Tadjkarimi S, Yacoub MH, Barnes PB, Belvisi MG (1995) 5- hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. Am J Respir Crit Care Med 152: 377–380

    PubMed  CAS  Google Scholar 

  143. Olszewski MA, Robinson NE, Zhu FX, Zhang XY, Tithof PK (1999) Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways. Am J Physiol 276: L522–L529

    PubMed  CAS  Google Scholar 

  144. Inoue H, Aizawa H, Miyazaki N, Ikeda T, Shigematsu N (1991) Possible roles of the peripheral vagal nerve in histamine-induced bronchoconstriction in guinea-pigs. Eur Respir J 4: 860–866

    PubMed  CAS  Google Scholar 

  145. Kikuchi Y, Okayama H, Ikayama M, Sasaki H, Takishima T (1984) Interaction between histamine and vagal stimulation on tracheal smooth muscle in dogs. J Appl Physiol: Respirat Environ Exercise Physiol 56: 590–595

    CAS  Google Scholar 

  146. Gustafsson LE, Wiklund NP, Cederqvist B (1986) Apparent enhancement of cholinergic transmission in rabbit bronchi via adenosine A2-receptors. Eur J Pharmacol 120: 179–185

    Article  PubMed  CAS  Google Scholar 

  147. Fernandes LB, Henry PJ, Rigby PJ, Goldie RG (1996) Endothelin(B) (ET(B)) receptor-activated potentiation of cholinergic nerve-mediated contraction in human bronchus. Br J Pharmacol 118: 1873–1874

    Article  PubMed  CAS  Google Scholar 

  148. Riccio MM, Reynolds CJ, Hay DWP, Proud D (1995) Effects of intranasal administration of endothelin-1 to allergic and nonallergic indivduals. Am J Respir Crit Care Med 152: 1757–1764

    PubMed  CAS  Google Scholar 

  149. Barnes PJ (1997) Autonomic control of the respiratory system. Harwood Academic Publishers, Amsterdam, The Netherlands, 139–184

    Google Scholar 

  150. Altiere RJ, Szarek JL, Diamond L (1985) Neurally mediated non-adrenergic relaxation in cat airways occurs independent of cholinergic mechanisms. J Pharmacol Exp Ther 254: 590–597

    Google Scholar 

  151. Stretton CD, Belvisi MG, Barnes PJ (1990) Neuropeptide Y modulates non-adrenergic, non-cholinergic neural bronchoconstriction in vivo and in vitro. Neuropeptides 17: 163–170

    Article  CAS  Google Scholar 

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  1. Johns Hopkins Asthma & Allergy Center, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD, 21224, USA

    Bradley J. Undem & Allen C. Myers

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  1. Dept. of Molecular Pharmacology, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

    Johan Zaagsma  & Herman Meurs  & 

  2. Department of Research Management, Pharma Bio-Research Group B.V., P.O. Box 200, 9470 AE, Zuidlaren, The Netherlands

    Ad F. Roffel

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Undem, B.J., Myers, A.C. (2001). Cholinergic and noncholinergic parasympathetic control of airway smooth muscle. In: Zaagsma, J., Meurs, H., Roffel, A.F. (eds) Muscarinic Receptors in Airways Diseases. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8358-0_1

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  • DOI: https://doi.org/10.1007/978-3-0348-8358-0_1

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