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The gero-inflammatory manifold

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Neuroinflammatory Mechanisms in Alzheimer’s Disease Basic and Clinical Research

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Inflammatory processes during Alzheimer’s disease (AD) may be considered as part of a larger manifold of oxidative and inflammatory processes that slowly develop during aging in many tissue beds throughout the organism as well as in the brain. Other chapters in this volume have described the many cellular and molecular interactions between aggregates of amyloid β-peptide (Aβ) and inflammatory system components. In considering whether inflammatory processes are primary or secondary during AD and in aging, we discuss evidence that inflammatory processes are associated with amyloid formation in many tissues. We also point out similarities and differences between AD and brain aging changes in humans and in various laboratory models. Moreover, some experimental and clinical interventions of aging in the brain and in non-neural tissues may work by modulating oxidative and inflammatory processes through systemic physiological factors. Thus, inflammatory processes during AD could be considered in a larger systemic context of age-related pathobiology which we designate the gero-inflammatory manifold (Fig. 1).

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Authors and Affiliations

  1. Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, 90089-0191, USA

    Caleb E. Finch & Valter D. Longo

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  1. Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ, 85372, USA

    Joseph Rogers

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Finch, C.E., Longo, V.D. (2001). The gero-inflammatory manifold. In: Rogers, J. (eds) Neuroinflammatory Mechanisms in Alzheimer’s Disease Basic and Clinical Research. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8350-4_13

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  • DOI: https://doi.org/10.1007/978-3-0348-8350-4_13

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9529-3

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