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Interleukin-10 in cerebral ischemia and stroke

  • Chapter
Inflammation and Stroke

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Ischemic neuronal cell death induced by transient ischemic attacks, cardiopulmonary arrest followed by resuscitation and acute stroke are leading causes of death and disability in industrialized countries. Early (< 3 h) treatment with tissue plasminogin activator (t-PA) was approved in 1996 for the treatment of acute stroke [1]. Nevertheless, the therapeutic challenge remains to determine what specific pharmacologic or nonpharmagologic interventions can be developed to reduce neuronal cell death and functional abnormalities from strokes or ischemic injury. In this regard, inflammatory processes are thought to participate in neuronal cell death following cerebral ischemia.

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Author information

Authors and Affiliations

  1. The Miami Project to Cure Paralysis, University of Miami School of Medicine, P.O. Box 016960 (R-48), Miami, FL, 33101, USA

    John R. Bethea & W. Dalton Dietrich

  2. Departments of Neurological Surgery, University of Miami School of Medicine, P.O. Box 016960 (R-48), Miami, FL, 33101, USA

    John R. Bethea & W. Dalton Dietrich

  3. Departments of Neurology, University of Miami School of Medicine, P.O. Box 016960 (R-48), Miami, FL, 33101, USA

    Ricardo Prado & W. Dalton Dietrich

Authors
  1. John R. Bethea
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  2. Ricardo Prado
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  3. W. Dalton Dietrich
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Editor information

Editors and Affiliations

  1. Cardiovascular Diseases Research Experimental Station, DuPont Pharmaceuticals Company, Route 141 & Henry Clay Road, Wilmington, DE, 19880, USA

    Giora Z. Feuerstein

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© 2001 Springer Basel AG

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Bethea, J.R., Prado, R., Dietrich, W.D. (2001). Interleukin-10 in cerebral ischemia and stroke. In: Feuerstein, G.Z. (eds) Inflammation and Stroke. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8297-2_11

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  • DOI: https://doi.org/10.1007/978-3-0348-8297-2_11

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9508-8

  • Online ISBN: 978-3-0348-8297-2

  • eBook Packages: Springer Book Archive

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