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Nitric Oxide and Inflammation pp 225–248Cite as

Birkhäuser

Nitric oxide in shock: sepsis and hemorrhage

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The past decade of nitric oxide (NO) research was highlighted by the awarding of the 1998 Nobel Prize in Physiology and Medicine to Drs. Robert Furchgott, Louis Ignarro, and Ferid Murad for their discoveries that endothelial cells synthesize nitric oxide (NO), and that endothelial derived NO regulates vascular smooth muscle relaxation. Although NO is one of the smallest synthetic products of mammalian cells, its contributions are large. Continued research in the field of NO has not only emphasized the important physiologic functions of NO, but has revealed its paradoxical role in pathophysiologic states as well.

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Authors and Affiliations

  1. Department of Surgery, University of Pittsburgh, 676 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA, 15213, USA

    Carol A. McCloskey & Timothy R. Billiar

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  1. Carol A. McCloskey
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  2. Timothy R. Billiar
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Editors and Affiliations

  1. MetaPhore Pharmaceuticals, 3655 Vista Avenue, St. Louis, MO, 63110, USA

    Daniela Salvemini Ph.D.

  2. Department of Surgery, A1010 Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Timothy R. Billiar M.D.

  3. Department of Surgery, UPMC Montefiore, University of Pittsburgh, NW 653 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Yoram Vodovotz Ph.D.

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© 2001 Springer Basel AG

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McCloskey, C.A., Billiar, T.R. (2001). Nitric oxide in shock: sepsis and hemorrhage. In: Salvemini, D., Billiar, T.R., Vodovotz, Y. (eds) Nitric Oxide and Inflammation. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8241-5_14

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  • DOI: https://doi.org/10.1007/978-3-0348-8241-5_14

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9488-3

  • Online ISBN: 978-3-0348-8241-5

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