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Angiotensin II as a Mediator of Inflammation in Atherosclerosis

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Inflammatory and Infectious Basis of Atherosclerosis

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Atherosclerosis is the result of a complicated cascade of events in blood vessels leading to a reduction in arterial lumen and blockage. The disease may be considered an inflammatory disease, which results from the combined presence of hypercholesterolemia, high blood pressure and an activated renin-angiotensin system (RAS). The progression is through a number of steps involving endothelial cells, monocytes/macrophages and vascular smooth muscle cells (VSMC). The progression to complete blockage of the artery is a slow process taking several decades, but the end result can be sudden death, acute myocardial ischemia, or stroke.

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Authors and Affiliations

  1. Departments of Physiology and Medicine, College of Medicine, University of Florida, Box 100274, Gainesville, 32610, USA

    M. Ian Phillips, Shuntaro Kagiyama, Hongjiang Chen & Jay L. Mehta

Authors
  1. M. Ian Phillips
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  2. Shuntaro Kagiyama
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  3. Hongjiang Chen
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  4. Jay L. Mehta
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Editors and Affiliations

  1. Division of Cardiovascular Disease, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 532, Little Rock, AR, 72205-7199, USA

    Jay L. Mehta

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© 2001 Springer Basel AG

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Phillips, M.I., Kagiyama, S., Chen, H., Mehta, J.L. (2001). Angiotensin II as a Mediator of Inflammation in Atherosclerosis. In: Mehta, J.L. (eds) Inflammatory and Infectious Basis of Atherosclerosis. Progress in Inflammation Research. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8239-2_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8239-2_8

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9487-6

  • Online ISBN: 978-3-0348-8239-2

  • eBook Packages: Springer Book Archive

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