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Genetic variation at the HLA and TCR loci and the development of allergy and asthma

  • Adel H. Mansur
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Part of the Progress in Inflammation Research book series (PIR)

Abstract

Antigen-presenting cells (APCs), including B cells, airway dendritic cells, tissue macrophages, and skin Langerhans cells, engulf and process protein antigens into small peptides of approximately 12 to 17 amino acids in length. Processed peptides bind to the binding groove of the major histocompatibility molecules (MHC), forming a peptide-MHC complex that is translocated to the cell surface. The presented peptide is recognised by a specific T cell through its receptor the TCR. T cells also carry other surface molecules, which are important to antigen recognition. These include the TCR-associated CD3 molecule, CD4 molecules on helper T cells (CD4+ T cells), and CD8 on cytotoxic T cells (CD8+ T cells). CD4* T cell recognises processed peptides of exogenous antigens bound to the MHC class II, while CD8+ T cells generally recognise peptides processed from endogenous antigens (e.g., virally infected cells) that are bound to MHC class I.

Keywords

Allergic Bronchopulmonary Aspergillosis Experimental Allergic Encephalitis Cell Receptor Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Basel AG 2002

Authors and Affiliations

  • Adel H. Mansur
    • 1
  1. 1.Molecular Medicine Unit, Clinical Sciences BuildingSt. James’s University HospitalLeedsUK

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