Genetic regulation of specific IgE responsiveness

  • Nobuyuki Hizawa
Part of the Progress in Inflammation Research book series (PIR)


Allergic reactions are the result of specific immunoglobulin E (IgE) antibody production in response to common innocuous antigens. Atopic people are intrinsically prone to produce IgE antibodies against many different allergens. IgE antibody production is driven by antigen-specific Th2 cells that secrete a distinct repertoire of cytokines, including IL-4, IL-5, IL-6, IL-9, and IL-13. Specific IgE responsiveness toward house dust mite (HDM) is associated with asthma and bronchial hyperresponsiveness [1-3]. Specific IgE responses toward allergens derived from cats, dogs, cockroaches, and pollens also contribute significantly to the development of allergic diseases. In particular, a clear correlation was recently demonstrated among cockroach allergy, level of exposure to cockroaches, and asthma-related health problems in inner-city children [4]. Because of the impact that allergies have on public health, it is critical to identify susceptibility factors in the development of specific IgE responses toward common environmental allergens.


Human Leukocyte Antigen Human Leukocyte Antigen Class House Dust Mite Diesel Exhaust Particle Human Leukocyte Antigen Gene 
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© Springer Basel AG 2002

Authors and Affiliations

  • Nobuyuki Hizawa
    • 1
  1. 1.First Department of Medicine, School of MedicineHokkaido UniversitySapporoJapan

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